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ADAM10 — CTNNB1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: ADAM10 (ADAM10) → E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1) (modification, activates)
  Maretzky et al., Proc Natl Acad Sci U S A 2005, Wild-Bode et al., J Biol Chem 2006, Huguenin et al., PloS one 2008, Dittmer et al., Cell Mol Life Sci 2009, Wheelock et al., J Cell Biochem 1987
  Evidence: mutant phenotype, assay
• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: ADAM10 (ADAM10) → N-cad-CTF1/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1) (modification, activates)
  Reiss et al., EMBO J 2005, Uemura et al., Neurosci Lett 2006, Nakazora et al., Biochem Biophys Res Commun 2010
  Evidence: mutant phenotype, assay
• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: ADAM10 (ADAM10) → N-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1) (modification, activates)
  Reiss et al., EMBO J 2005, Uemura et al., Neurosci Lett 2006, Nakazora et al., Biochem Biophys Res Commun 2010
  Evidence: mutant phenotype, assay

Text-mined interactions from Literome

Reiss et al., EMBO J 2005 : Our data therefore demonstrate a crucial role of ADAM10 in the regulation of cell-cell adhesion and on beta-catenin signalling, leading to the conclusion that this protease constitutes a central switch in the signalling pathway from N-cadherin at the cell surface to beta-catenin/LEF-1 regulated gene expression in the nucleus
Maretzky et al., Proc Natl Acad Sci U S A 2005 : ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation