◀ Back to IGF1

IGF1 — TGFB1

Text-mined interactions from Literome

Edmondson et al., J Cell Physiol 1999 : Expression of insulin-like growth factor binding protein-3 ( IGFBP-3 ) in human keratinocytes is regulated by EGF and TGFbeta1
Voci et al., Eur J Endocrinol 1999 : IGF-I production by adult rat hepatocytes is stimulated by transforming growth factor-alpha and transforming growth factor-beta1 ... Our results demonstrate that TGF-alpha and TGF-beta1 significantly stimulate IGF-I and IGFBP secretion by cultured hepatocytes but no change in the abundance of IGF-I and IGFBP mRNAs was observed with respect to controls
Richardson et al., Acta Anat (Basel) 1992 : Effect of transforming growth factor-beta on insulin-like growth factor 1- and dexamethasone induced proliferation and differentiation in primary cultures of pig preadipocytes ... IGF-1 ( 10 nM ) enhanced preadipocyte differentiation ( p < 0.05 ) in serum supplemented ( 1 % pig serum ) cultures, whereas TGF-beta1 ( 15 pM ) reduced preadipocyte differentiation ( p < 0.01 ) in the presence and absence of IGF-1
Dahiya et al., Int J Impot Res 1999 (Erectile Dysfunction) : The results of these experiments suggest that : ( 1 ) young and old rat penile tissues expressed mRNA transcripts for TGF alpha, TGF beta 1, TGF beta 2, TGF beta 3, IGF and NGF ; ( 2 ) TGF beta 1 gene expression was significantly increased in old rat penile tissues as compared to young ; ( 3 ) mRNA transcripts for NGF and TGF beta 3 were significantly lower in old rat penile tissues as compared to young ; and ( 4 ) TGF alpha, TGF beta 2 and IGF mRNA expression did not change in young and old rat penile tissues
Huynh et al., Int J Oncol 2000 : In order to examine the hypothesis that IGF-I suppresses TGF-beta1 expression in the mammary gland, we studied the effect of various manipulations of the growth hormone - IGF-I axis on TGF-beta1 mRNA abundance
Ghahary et al., Growth Factors 2000 : Mannose-6-phosphate/IGF-II receptors mediate the effects of IGF-1 induced latent transforming growth factor beta 1 on expression of type I collagen and collagenase in dermal fibroblasts ... In this study we investigated whether IGF-1 induced latent TGF-beta 1 has autocrine effects on dermal fibroblasts and described a possible mechanism ... As the TGF-beta 1 induced by IGF-1 is inactive in the traditionally used mink lung epithelial cell growth inhibition assay, we explored the possible role of IGF-II/M6P receptors in facilitating these autocrine effects ... These findings suggest that IGF-1 induces latent TGF-beta 1 and that the matrix modulating autocrine effects of LTGF-beta 1 on dermal fibroblasts are facilitated by M6P/IGF-II receptors on these cells
Dahlfors et al., Endocrinology 2000 : Vascular endothelial growth factor and transforming growth factor-beta1 regulate the expression of insulin-like growth factor binding protein-3, -4, and -5 in large vessel endothelial cells ... Transforming growth factor-beta1 inhibited IGFBP-3 ( P < 0.01 ), IGFBP-4 ( P < 0.01 ), and IGF-I mRNA expression, whereas at the protein level only IGFBP-3 was significantly decreased
Vermes et al., J Bone Joint Surg Am 2001 (Osteolysis) : Exogenous tumor necrosis factor-alpha also enhanced the release of interleukin-6 ( p < 0.01 ) and transforming growth factor-beta1 ( p < 0.05 ), whereas the secretion of transforming growth factor-beta1 was increased by insulin-like growth factor-I and prostaglandin E2 as well
Kveiborg et al., APMIS 2002 : We have previously shown that TGF-beta1 increased IGF-I and IGF binding protein (IGFBP)-3 production in human bone marrow stromal ( hMS ) osteoblast progenitors and calcitriol stimulated IGFBP-3 and IGFBP-4 production
Daian et al., J Invest Dermatol 2003 (Keloid) : Insulin-like growth factor-I enhances transforming growth factor-beta induced extracellular matrix protein production through the P38/activating transcription factor-2 signaling pathway in keloid fibroblasts ... Insulin-like growth factor-I and transforming growth factor-beta1 costimulation markedly increased extracellular matrix proteins ( collagen type I, fibronectin, and plasminogen activator inhibitor-1 ) compared with cultures with transforming growth factor-beta1 alone ... These results indicate that insulin-like growth factor-I enhances transforming growth factor-beta induced keloid formation through transforming growth factor-beta postreceptor signal cross-talk, mainly via the p38 mitogen activated protein kinase/activating transcription factor-2 pathway
Mincione et al., Exp Cell Res 2003 : Transforming growth factor beta 1 ( TGF-beta 1 ) and insulin-like growth factor I (IGF-I) have contrasting effects on cell cycle regulation in thyroid cells and TGF-beta 1 induces a dramatic decrease in IGF-I induced cell proliferation
Zarzyńska et al., J Dairy Res 2005 : Exogenous TGF-beta1, IGF-I , EGF and GH inhibited FBS-deficiency stimulated TGF-beta1 expression ... Exogenous TGF-beta1, IGF-I , EGF and GH inhibited FBS-deficiency stimulated TGF-beta1 expression
Zarzyńska et al., J Physiol Pharmacol 2005 : Dissimilar effects of LY 294002 and PD 098059 in IGF-I mediated inhibition of TGF-beta1 expression and apoptosis in bovine mammary epithelial cells ... An inhibition of ERK1/2 pathway even potentiated inhibitory effect of IGF-I on TGF-beta(1) expression, but partially abrogated anti-apoptotic effect of IGF-I
Song et al., EMBO J 2006 : Insulin-like growth factor-I inhibits transforming growth factor-beta ( TGF-beta ) signaling by blocking activation of Smad3 (S3), via a phosphatidylinositol 3-kinase (PI3K)/Akt dependent pathway
Sakimura et al., Cells Tissues Organs 2006 (Arthritis, Rheumatoid...) : Effects of insulin-like growth factor I on transforming growth factor beta1 induced chondrogenesis of synovium derived mesenchymal stem cells cultured in a polyglycolic acid scaffold
Kawada et al., Anticancer Res 2008 (Prostatic Neoplasms) : TGF-beta1 increased the expression of IGF-I and IGF binding protein-3 (IGFBP-3)
Elford et al., Endocrinology 1990 : In this study the effect of TGF beta-1 on immunoreactive IGF-I production by osteoblasts and chondrocytes was investigated and compared to that of PTH on osteoblasts or basic fibroblast growth factor (bFGF) on chondrocytes ... Both TGF beta-1 and PTH stimulated IGF-I release from osteoblasts, which was further enhanced when both were consecutively present
Mondschein et al., Endocrinology 1988 : Effects of transforming growth factor-beta on the production of immunoreactive insulin-like growth factor I and progesterone and on [ 3H ] thymidine incorporation in porcine granulosa cell cultures
Okazaki et al., Biochem Biophys Res Commun 1995 : Previous studies in rat osteoblastic cells have indicated that transforming growth factor-beta ( TGF-beta ) inhibits IGF-I expression, whereas inducers of intracellular cAMP stimulate IGF-I expression
Wikiel et al., Biochim Biophys Acta 1994 (Leukemia, Myeloid, Acute) : In the absence of serum, growth of ML-1 human myeloblastic leukemia cells is induced by the insulin-like growth factor-1 (IGF1) together with transferrin (Tf), whereas monocytic differentiation is initiated by the transforming growth factor-beta ( TGF-beta ) in combination with Tf. Initiation of growth was followed by the rapid release of arachidonic acid ( AA ), hydroxyeicosatetraenoic acids ( HETEs ) and phospholipids into the culture medium
Canalis et al., Endocrinology 1993 : We tested the effects of basic fibroblast growth factor (bFGF), transforming growth factor-beta 1 ( TGF beta 1 ), and platelet derived growth factors (PDGF) AA and BB on IGF-I mRNA expression and polypeptide concentrations in cultures of osteoblast enriched ( Ob ) cells from 22-day-old fetal rat calvariae
Hembree et al., J Anim Sci 1996 : Cultured porcine myogenic cells produce insulin-like growth factor binding protein-3 ( IGFBP-3 ) and transforming growth factor beta-1 stimulates IGFBP-3 production
Rydziel et al., Endocrinology 1996 : In conclusion, normal Ob cells express the PDGF-B gene, and TGF beta 1 induces its transcription, whereas bFGF, IGF-I , and PDGF-BB do not enhance the levels of PDGF-B mRNA
Erondu et al., Endocrinology 1997 : IGFBP-3 is regulated by a number of growth factors/cytokines to which the vascular endothelium is exposed, including IGF-I stimulation and TGF-beta1 inhibition of IGFBP-3 in cultured endothelial cells
Ghahary et al., J Cell Physiol 1998 : Induction of transforming growth factor beta 1 by insulin-like growth factor-1 in dermal fibroblasts ... An increase in IGF-1 induced TGF-beta1 should be important in many different physiological processes such as cellular proliferation, differentiation, and wound healing
Lacroix et al., Cancer Lett 1998 (Breast Neoplasms) : The production of Il-11 was increased by transforming growth factor-beta1 in a dose dependent manner with a rapid ( 2 h ) and transient ( 24 h ) mRNA induction, but not by epidermal growth factor, insulin-like growth factor-I and -II, basic fibroblast growth factor, platelet derived growth factor or parathyroid hormone