Gene interactions and pathways from curated databases and text-mining

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IGF1 — IGF1R

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Pandini et al., Clin Cancer Res 1999 (Breast Neoplasms) : Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression : evidence for a second mechanism of IGF-I signaling
Seiler et al., Alcohol Clin Exp Res 2000 (MAP Kinase Signaling System) : Activation of the insulin-like growth factor I receptor ( IGF-IR ) by its ligands IGF-I and IGF-II induces cell proliferation and protects against apoptosis
Cheng et al., J Biol Chem 2000 (MAP Kinase Signaling System) : In parallel, IGF-I activates IGF-I receptor , insulin receptor substrate-1 (IRS-1), phosphatidylinositol 3 (PI-3)-kinase, and FAK
Yam et al., J Biol Chem 2001 (MAP Kinase Signaling System) : Characterization of insulin-like growth factor I (IGF-I) receptor mutants for their effects on IGF-I- and interleukin 4-mediated DNA synthesis of 32D cells
Brown et al., Domest Anim Endocrinol 2001 : Specific aims were to measure the levels of IGF binding protein-3 (IGFBP-3) and RNA encoding IGFBP-3 in the CL throughout diestrus, and to investigate the effects of IGFBP-2 and -3 on IGF-I stimulated progesterone ( P4 ) production and IGF-I-receptor binding
Huang et al., FEBS Lett 2001 : SPR measurements showed that the tyrosine phosphorylation of IGF-1R induced by its extracellular ligand insulin-like growth factor-1 caused the receptor to bind with IRS-1 10 times faster than the unactivated receptor
Bostedt et al., Exp Cell Res 2001 (Bone Neoplasms...) : We compared the growth rates, IGFBP production, IGF I binding characteristics, IGF 1R protein and mRNA levels, and the acute IGF I response ( stimulation of glycogen synthesis ) after pretreatment of the cells in serum-free medium with or without added IGF I or medium supplemented with 5 % fetal calf serum ( FCS )
Devi et al., Growth Horm IGF Res 2001 : Effect of IGFBP-3 on IGF- and IGF-analogue induced insulin-like growth factor-I receptor ( IGFIR ) signalling
Oh et al., Neoplasia (New York, N.Y.) 2002 (Disease Progression...) : Activation of the insulin-like growth factor-1 receptor ( IGF-1R ) by IGF-1 is associated with the risk and progression of many types of cancer, although despite this it remains unclear how activated IGF-1R contributes to cancer progression
Zizola et al., Biochimie 2002 : We propose an autocrine and/or paracrine action of IGF-I in this adipocyte differentiation model, where IGF-I produced by the differentiating preadipocytes acts over their adjacent cells and, in this way, diminishes the expression of IGF-I receptor
Mincione et al., Exp Cell Res 2003 : Moreover, TGF-beta 1 decreased the IGF-I induced tyrosine phosphorylation of the adaptor protein CrkII and its association with the IGF-I receptor
Ohlsson et al., J Endocrinol 1992 : The effects of tri-iodothyronine ( T3 ) and insulin-like growth factor-I (IGF-I) on [ 3H ] thymidine incorporation, alkaline phosphatase (ALP) activity and IGF-I receptor mRNA levels were studied in rat epiphyseal chondrocytes cultured in monolayer
Sall et al., Exp Eye Res 2004 : IGF-1 induced a dose dependent increase in IGF-1R phosphorylation and in VEGF mRNA levels in cultured human RPE cells
Rose et al., J Biol Chem 2004 (MAP Kinase Signaling System) : We found that IGF-1 activated the IGF-1R , insulin receptor substrate (IRS)-1, phosphatidylinositol 3-kinase, and Akt in a time dependent manner in alphaT3 cells
Moralez et al., J Cell Physiol 2005 (MAP Kinase Signaling System) : When the IGFBP-5 mutant that did not bind to IGF-I was incubated with TS-1 and IGF-I, it inhibited the capacity of TS-1 to enhance the IGF-I receptor phosphorylation and MAP kinase activation in response to IGF-I
Nakamura et al., Biochem Biophys Res Commun 2005 : MMP-7 cleaved all six IGFBPs, resulting in IGF mediated IGF-1R phosphorylation, which was inhibited by EDTA treatment
Kuemmerle et al., Am J Physiol Gastrointest Liver Physiol 2006 : In the presence of the alpha ( v ) beta ( 3 ) -ligand fibronectin, IGF-I stimulated IGF-I receptor activation was augmented ... Conversely, in the presence of the alpha ( v ) beta ( 3 ) -specific disintegrin echistatin, IGF-I stimulated IGF-I receptor tyrosine kinase phosphorylation was inhibited ... IGF-I stimulated IGF-I receptor activation was accompanied by recruitment of the adapter protein IRS-1, activation of Erk1/2, p70S6 kinase, and proliferation ... The results show that occupancy of the alpha(v)beta(3)-integrin receptor modulates IGF-I induced IGF-I receptor activation and function in human intestinal muscle cells ... We hypothesize that the concomitant increases in the expression of alpha ( v ) beta ( 3 ) -ligands and of IGF-I in active Crohn 's disease may contribute to muscle hyperplasia and stricture formation by acting in concert to augment IGF-I stimulated IGF-I receptor tyrosine kinase activity and IGF-I mediated muscle cell growth
Nguyen et al., Br J Pharmacol 2005 (Body Weight) : Intravenous IGF-I receptor antisense reduces IGF-IR expression and diminishes pressor responses to angiotensin II in conscious normotensive rats
Vasilcanu et al., Oncogene 2006 (Neoplasms) : These two cell lines were demonstrated not to acquire any essential alteration in responsiveness to PPP regarding IGF-1 induced IGF-1R phosphorylation
Bhaumick et al., Horm Res 1991 : Epidermal growth factor enhancement of insulin-like growth factor-I induced down-regulation of insulin-like growth factor I receptor in cultured placental trophoblastic cells ... The time required to initiate the IGF-I induced down-regulation of IGF-I receptor was reduced by 4 h in the presence of EGF
Keyhanfar et al., Hybridoma (Larchmt) 2006 : Activation of the IGF-1R by IGF-I and IGF-II binding to the extracellular domains of the receptor induces mitogenic and anti-apoptotic effects, which are important events in tumor growth and survival
Aishima et al., Cancer Sci 2006 (Carcinoma, Hepatocellular...) : IGF-I enhanced the phosphorylation of IGF-1R , Akt and Erk1/2 in KYN-2 cells, and coadministration of IGFBP-3 blocked all types of activation by IGF-I investigated here
Duronio et al., Biochem J 1990 : The increase in phosphorylation of insulin receptor in response to IGF-I correlated with the dose-response of IGF-I stimulated phosphorylation of the IGF-I receptor
Fang et al., Carcinogenesis 2007 (Prostatic Neoplasms) : Luteolin inhibited insulin-like growth factor 1 (IGF-1) induced activation of IGF-1R and AKT in prostate cancer PC-3 and DU145 cells
Elliot et al., J Am Soc Nephrol 2006 (Albuminuria...) : Mesangial cells that were isolated from S/Pla mice had an increase of IGF-I receptor protein, and IGF-I stimulated a TGF-beta reporter construct promoter three-fold
Zeger et al., Glia 2007 : These results indicate that IGF-I directly affects oligodendrocytes and myelination in vivo via IGF1R, and that IGF1R signaling in the cells of oligodendrocyte lineage is required for normal oligodendrocyte development and myelination
Zhang et al., Cancer Res 2007 (Breast Neoplasms) : We used small interfering RNA ( siRNA ) technology to specifically down-regulate IGF1R by 60 % to 80 % in the MDA-435/LCC6 cell line, which was sufficient to diminish activation of IGF1R by IGF-I
Cahill et al., Cell Mol Neurobiol 1991 : The tyrosine kinase activity of the IGF-I receptor presumably mediates the effects of IGF-I on chromaffin cell function
Niu et al., J Biol Chem 2007 (Atherosclerosis...) : IGF-1 markedly enhanced IGF-1R phosphorylation in both wild-type and LAR ( -/- ) VSMC, but the phosphorylation was 90 % higher in knock-out cells compared with wild-type cells
Chabrolle et al., Reproduction 2007 : Furthermore, it improved IGF-I induced IGF-I receptor-beta subunit tyrosine phosphorylation and ERK1/2 phosphorylation
Gauguin et al., J Biol Chem 2008 : Evidence suggests that insulin-like growth factor-I (IGF-I) may activate the IGF-I receptor in a similar mode
Xi et al., Mol Endocrinol 2008 : In contrast, knockdown of p66shc did not affect IGF-I stimulated IGF-I receptor tyrosine phosphorylation
Sunstrom et al., Cytotechnology 1998 : In particular, the expression of the endogenous IGF-I receptor in response to IGF-I production has not been reported
Broussas et al., Int J Cancer 2009 (MAP Kinase Signaling System) : Here, we showed that h7C10 inhibited IGF-1 induced IGF-1R phosphorylation in a dose dependent manner
Chen et al., J Nutr 2009 (Prostatic Neoplasms) : At nutritionally relevant concentrations ( 20-60 micromol/L ), enterolactone inhibited IGF-1 induced activation of IGF-1R and its downstream AKT and mitogen activated protein kinase/extracellular-signal regulated kinase signaling pathways
Barbosa et al., Pituitary 2011 (Acromegaly...) : It is known that GH and IGF-I can activate B cell lymphocytes, and that IGF-I receptor is universally expressed in MM cells
Saegusa et al., J Biol Chem 2009 : Furthermore wild type IGF-1 mediated co-precipitation of alphavbeta3 and IGF1R, whereas the R36E/R37E mutant did not, suggesting that IGF-1 mediates the interaction between alphavbeta3 and IGF1R
Giovannone et al., Hum Mol Genet 2009 (Disease Models, Animal...) : Primary cultured embryo fibroblasts from Gigyf2 null mice exhibit decreased IGF-I stimulated IGF-I receptor tyrosine phosphorylation and augmented ERK1/2 phosphorylation
Mani et al., Reproduction 2010 : IGF1 with FSH resulted in a synergistic increase in granulosa cell number and in mRNA expression of CYP19A1 and IGF1R without altering OE(2) production
Park et al., Haematologica 2010 (Leukemia, Myeloid, Acute) : Constitutive PI3K activation is the result of autocrine IGF-1/IGF-1R signaling in 70 % of acute myeloid leukemia samples but specific inhibition of this pathway does not induce apoptosis
Chapuis et al., Haematologica 2010 (Blast Crisis...) : Autocrine IGF-1/IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia : therapeutic value of neutralizing anti-IGF-1R antibody ... Autocrine IGF-1/IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia : therapeutic value of neutralizing anti-IGF-1R antibody
Nemoto et al., Neuropharmacology 2010 : Thus, IGF-I down-regulated functional IGF-I receptor via GSK-3beta inhibition and mTOR activation ; constitutive activity of GSK-3beta maintained IGF-I receptor level in nonstimulated cells ... Thus, IGF-I down-regulated functional IGF-I receptor via GSK-3beta inhibition and mTOR activation ; constitutive activity of GSK-3beta maintained IGF-I receptor level in nonstimulated cells
Furundzija et al., Biochem Biophys Res Commun 2010 (Atherosclerosis) : Pharmacological blocking experiments with specific inhibitors of Akt, PKC and p38 MAP-kinase revealed that IGF-1 dependent activation of focal adhesion kinase ( FAK ) and paxillin, and consecutively IGF-1 facilitated migration, required IGF-1/IGF-1R mediated PI3-kinase/PKC/p38 dependent integrin inside-out signaling ... Pharmacological blocking experiments with specific inhibitors of Akt, PKC and p38 MAP-kinase revealed that IGF-1 dependent activation of focal adhesion kinase ( FAK ) and paxillin, and consecutively IGF-1 facilitated migration, required IGF-1/IGF-1R mediated PI3-kinase/PKC/p38 dependent integrin inside-out signaling ... Pharmacological blocking experiments with specific inhibitors of Akt, PKC and p38 MAP-kinase revealed that IGF-1 dependent activation of focal adhesion kinase ( FAK ) and paxillin, and consecutively IGF-1 facilitated migration, required IGF-1/IGF-1R mediated PI3-kinase/PKC/p38 dependent integrin inside-out signaling ... Pharmacological blocking experiments with specific inhibitors of Akt, PKC and p38 MAP-kinase revealed that IGF-1 dependent activation of focal adhesion kinase ( FAK ) and paxillin , and consecutively IGF-1 facilitated migration, required IGF-1/IGF-1R mediated PI3-kinase/PKC/p38 dependent integrin inside-out signaling
Bolós et al., J Biol Chem 2010 (Alzheimer Disease) : The transport mechanism for IGF-I in this specialized epithelium involves the IGF-I receptor and the membrane multicargo transporter megalin/LRP2
Garcia-Segura et al., Prog Brain Res 2010 : The molecular mechanisms involved in the interaction of estradiol and IGF-I include the cross-regulation of the expression of estrogen and IGF-I receptors, the regulation of estrogen receptor mediated transcription by IGF-I and the regulation of IGF-I receptor signalling by estradiol
Sugita et al., Mol Cancer Res 2010 (Neoplasm Invasiveness...) : NO donor inhibited insulin/IGF-I stimulated phosphorylation of insulin receptor/IGF-I receptor , IRS-1, Akt/PKB, and glycogen synthase kinase-3beta along with decreased expression of IRS-1 protein in MIAPaCa-2 cells, whereas NO donor enhanced the phosphorylation of extracellular signal regulated kinase-1/2
Aleksic et al., Cancer Res 2010 (Breast Neoplasms...) : The IGF dependence of these phenomena indicates a requirement for the receptor kinase, and indeed, IGF-1R nuclear import and chromatin binding can be blocked by a novel IGF-1R kinase inhibitor
Cascella et al., Endocrinology 2010 : Aldosterone resulted in significant increases in the Akt ( 1.87 ± 0.24, P < 0.001 ), MAPK ( 1.78 ± 0.13, P < 0.001 ), p70S6kinase ( 1.92 ± 0.15, P < 0.001 ), IGF-I receptor ( 1.69 ± 0.05, P < 0.01 ), and insulin receptor substrate-1 ( 1.7 ± 0.04, P < 0.01 ) ( fold increase, mean ± SEM, n = 3 ) phosphorylation responses to IGF-I compared with IGF-I treatment alone
Tsai et al., J Nutr Biochem 2011 (Neovascularization, Pathologic) : Western blotting and immunoprecipitation demonstrated that denbinobin causes more efficient inhibition of IGF-1 induced activation of IGF-1R and its downstream signaling targets, including, extracellular signal regulated kinase, Akt, mTOR, p70S6K, 4EBP and cyclin D1
Huang et al., J Biol Chem 2010 : In addition to inhibiting insulin receptor and IGF1R kinase activity by directly binding to the receptors, GRB10 can also negatively regulate insulin and IGF1 signaling by mediating insulin receptor and IGF1R degradation through ubiquitination
Riesterer et al., Int J Radiat Oncol Biol Phys 2011 (Carcinoma, Non-Small-Cell Lung...) : Cell lines were assessed for IGF-1R expression and IGF1 dependent response to A12 or radiation using viability and clonogenic cancer cell survival assays
Sanchez-Alavez et al., J Biol Chem 2011 (Fever) : These data indicate a novel thermoregulatory role for both IGF-1R and neuronal insulin receptors in IGF-1 activation of BAT and hyperthermia
Chakravarti et al., Mol Cell Endocrinol 2011 (Breast Neoplasms) : Accordingly THBP was found to inhibit IGF-1 induced phosphorylation of IGF-1R and insulin receptor substrate-1 (IRS-1) without inhibiting insulin signaling in MCF-7 cells
Jaquish et al., Carcinogenesis 2011 (Pancreatic Neoplasms) : IGF-1 induces rapid phosphorylation of RON, but RON signaling did not activate IGF-1R indicating unidirectional signaling between these RTKs
Zhang et al., Breast Cancer Res 2011 (Breast Neoplasms) : In the present study, we sought to elucidate whether antiestrogen resistance is induced directly by IGF-1R signaling in response to its ligand IGF-1 stimulation ... Ectopic expression of IGF-1R in ER-positive MCF7 human breast cancer cells enhanced IGF-1R tyrosine kinase signaling in response to IGF-1 ligand stimulation
Steele-Perkins et al., Biochem Biophys Res Commun 1990 : Moreover, this antibody inhibits the ability of both IGF-I and II to stimulate the kinase activity of the IGF-I receptor in intact cells
King et al., Gynecol Oncol 2011 (Cystadenocarcinoma, Serous...) : Additionally, low-grade SOC cell lines were more responsive to IGF-1 stimulation and IGF-1R inhibition than were high-grade lines
Jiang et al., Am J Physiol Endocrinol Metab 2011 (MAP Kinase Signaling System) : In carp pituitary cells, IGF-I and -II could induce rapid phosphorylation of IGF-I receptor , MEK1/2, ERK1/2, MKK3/6, and p38 MAPK ; and SLa and SLß secretion, protein production, and mRNA expression caused by IGF-I and -II stimulation were negated by inactivating MEK1/2 and p38 MAPK ... In carp pituitary cells, IGF-I and -II could induce rapid phosphorylation of IGF-I receptor , MEK1/2, ERK1/2, MKK3/6, and p38 MAPK ; and SLa and SLß secretion, protein production, and mRNA expression caused by IGF-I and -II stimulation were negated by inactivating MEK1/2 and p38 MAPK
Huang et al., Nutr Cancer 2011 (Prostatic Neoplasms) : These results demonstrated that Zyflamend inhibited IGF-1 stimulated cell growth, IGF-1R expression, and androgen receptor expression and its nuclear localization, but these effects were not dependent upon phosphatidylinositol 3-kinase/pAKT signaling
Matsumoto et al., In Vitro Cell Dev Biol Anim 2011 : IGF1R expression is increased by SW ; however, IGF2R expression did not increase by SW
Bid et al., Mol Cancer Ther 2012 (Neovascularization, Pathologic...) : Immunoprecipitation using anti-IGF-1R and anti-IN-R antibodies revealed that SCH717454 equally blocked IGF-1 stimulated and IGF-2 stimulated IGF-1R phosphorylation, but not IGF-2 stimulated phosphorylation of IN-R
Fujita et al., J Biol Chem 2012 : We recently reported that IGF1 directly binds to avß3 and induces avß3-IGF1-IGF1R ternary complex formation ... WT IGF1 induced a6ß4-IGF1-IGF1R ternary complex formation, whereas R36E/R37E did not
Chand et al., J Immunol 2012 (Chronic Disease...) : Blocking epidermal growth factor receptor or IGF-1R activation also suppressed IC-IGF-1 and abolished the Bcl-2 induction
Ku et al., Mol Nutr Food Res 2012 : Furthermore, EGCG inhibited the IGF-I stimulated phosphorylation of the IGF-I receptor-beta ( IGF-IR ß ), the association of IGF-IR with the p66Shc protein, and the IGF-II stimulated associations of the IGF-II receptor with G ( ai-2 ) and p66Shc proteins, suggesting that EGCG selectively affects particular types of Shc and MAPK family members
Fagan et al., Cancer Res 2012 (Breast Neoplasms) : An IGF1R tyrosine kinase inhibitor, AEW541, with equal potency for the IGF1R and IR, inhibited IGF-I- , IGF-II-, and insulin stimulated Akt phosphorylation, proliferation, and anchorage independent growth in parental cells
Goel et al., Cancer Discov 2012 (Prostatic Neoplasms) : VEGF/NRP2 signaling represses insulin-like growth factor-1 receptor ( IGF-IR ) expression and signaling, and the mechanism involves Bmi-1 mediated transcriptional repression of the IGF-IR
Kraus et al., Biol Chem 2012 (Prostatic Neoplasms) : Cathepsin X deficiency leads to a reduced phosphorylation of the IGF-I receptor in response to IGF-I stimulation
Fujita et al., J Biol Chem 2013 : We reported previously that IGF1 directly binds to avß3 and induces avß3-IGF1-IGF1R ternary complex formation in these conditions ... Inhibitors of IGF1R , Src, AKT, and ERK1/2 did not suppress avß3-IGF-IGF1R ternary complex formation, suggesting that activation of these kinases are not required for ternary complex formation
Bitelman et al., Cancer Lett 2013 (Endometrial Neoplasms) : In addition, pretreatment with MK-0646 decreased the IGF1 induced phosphorylation of IGF1R , AKT and ERK
Varkaris et al., Int J Cancer 2013 (Prostatic Neoplasms) : Ligand independent activation of MET through IGF-1/IGF-1R signaling
Youreva et al., Can J Physiol Pharmacol 2013 : In this study, we determined the effect of curcumin on IGF-1 induced phosphorylation of protein kinase B (PKB), glycogen synthase kinase-3ß ( GSK-3ß ), and IGF-1R in VSMC
Reverchon et al., Fertil Steril 2013 (Infertility, Female) : This was associated with a reduction in the P450 aromatase and P450scc ( cholesterol side-chain cleavage cytochromes P450 ) ( P450scc ) protein levels but not those of 3ß-hydroxysteroid dehydrogenase ( 3ß-HSD ) or steroidogenic acute regulatory protein ( StAR ) and with a decrease in IGF-I induced IGF-I receptor and mitogen activated protein kinase ( MAPK ) extracellular signal regulated kinase 1/2 ( ERK1/2 ) phosphorylation
Peled et al., Cellular oncology (Dordrecht) 2013 : Neither a knock-down of IGF-1R expression nor an activation of the IGF1-R pathway through exogenous IGF-1 expression affected gefitinib sensitivity
Shen et al., FEBS open bio 2012 : We found that both IGF-1 and sunitinib obviously down regulated the IGF-1R expression
Gates et al., J Recept Res 1987 : An IGF-I receptor monoclonal antibody ( alpha IR-3 ) inhibited 125I-IGF-I but not 125I-insulin binding
Arnqvist et al., Metabolism 1995 : The IGF-I receptor is highly expressed in SMCs in intact arteries and in cultured SMCs and is activated by binding of IGF-I to the two alpha-subunits
Lopaczynski et al., Regul Pept 1993 (Osteosarcoma) : Insulin-like growth factor-I (IGF-I) dependent phosphorylation of the IGF-I receptor in MG-63 cells
Reeve et al., J Biol Chem 1995 (Cell Transformation, Viral) : The reduced growth factor requirements of murine fibroblasts transformed by simian virus 40 ( SV 40 ) have been attributed to insulin-like growth factor (IGF)-I induction by T antigen and consequent activation of IGF-I receptor signaling
Rosenthal et al., J Endocrinol 1994 : Thus, IGF-II induces IGF-I receptor down-regulation in muscle cells through multiple mechanisms, including decreasing IGF-I receptor mRNA and stimulating IGF-I receptor protein degradation
Doherty et al., Mol Reprod Dev 1994 : Although mouse preimplantation embryos express transcripts for the insulin-like growth factor-I receptor ( IGF-IR ), IGF-I transcripts were not detected by reverse transcription-PCR ( RT-PCR ) at any stage of preimplantation development in a previous study ( Rappolee et al., Genes Dev 6 : 939-952, 1992 )
Galiano et al., J Clin Invest 1996 (Skin Ulcer) : Our results suggest that activation of both the IGF-I receptor and the alpha5beta1 integrin is required for IGF-I to stimulate wound healing
Lee et al., J Endocrinol 1997 (Breast Neoplasms) : Although TAM can increase IGFBP-3 expression in MCF-7 cells, and this binding protein has been shown to be able to inhibit IGF action, TAM had no effect on IGF-I stimulated tyrosine phosphorylation of IGF-I receptor or the downstream signaling molecule, insulin receptor substrate-1
Karas et al., J Biol Chem 1997 (Endometrial Neoplasms) : Membrane associated insulin-like growth factor binding protein-3 inhibits insulin-like growth factor-I induced insulin-like growth factor-I receptor signaling in ishikawa endometrial cancer cells
Pugliese et al., Diabetes 1997 : Both human and rat mesangial cells grown on BSA-AGE showed increased IGF-I and total and bioactive TGF-beta medium levels and enhanced IGF-I, IGF-II, and TGF-beta1 gene expression, compared with cells grown on BSA, whereas total IGFBP and IGFBP-3 medium content, IGF receptor density and affinity, and IGF-I receptor transcripts were unchanged
Sun et al., Cardiovasc Res 1998 : NE treatment significantly increased IGF-1 mRNA levels in both left- and right-ventricle ; however, levels of IGF-1R increased in the left- but not the right-ventricle
Cheng et al., J Biol Chem 1998 : We have previously shown that insulin-like growth factor I (IGF-I) activation of the IGF-I receptor rescues SH-SY5Y human neuroblastoma cells from high glucose mediated programmed cell death (PCD)
Schillaci et al., Cell Immunol 1998 : Consequently the regulation of IGF-1R expression by IGF-1 and the activation events in human blood T lymphocytes and the Jurkat T cell line were now investigated
Li et al., Exp Cell Res 1998 : A well characterized substrate of the IGF-1 R, IRS-1, is constitutively phosphorylated by the Delta870-905 IGF-1 R and phosphoinositide (PI) 3-kinase activity, which is normally activated by the phosphorylation of IRS-1 following IGF-1 stimulation, is increased even in the absence of IGF-1
Kobari et al., Int J Pancreatol 1998 (Pancreatic Neoplasms) : The inhibiting IGF-1-R-Ab reduced the cell number and suppressed the IGF-1 stimulated increase after 24 h and later it induced an increased cell number
Lighten et al., Hum Reprod 1998 : Immunocytochemistry using an alphaIR3 antibody confirmed the presence of IGF-I receptor in human blastocysts and the same antibody completely inhibited the stimulation of blastocyst formation by IGF-I