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IRF6 — SLC9A1
Text-mined interactions from Literome
Cetin et al., Surgery 2004
(Acidosis...) :
LPS caused a dose dependent reduction in basolateral
NHE1 activity in IEC-6 cells, but had no effect on apical NHE3 activity ...
LPS selectively
impairs basolateral
NHE1 but not apical NHE3, leading to cytoplasmic acidification during extracellular acidosis
Cui et al., Acta Pharmacol Sin 2013
(Atherosclerosis) :
Amiloride ( 1-10 µmol/L ) significantly suppressed
LPS induced increases in
NHE1 activity, [ Ca ( 2+ ) ] ( i ) ...
LPS stimulates
NHE1 activity, increases [ Ca ( 2+ ) ] ( i ), and activates calpain, which leads to endothelial cell apoptosis related to decreased Bcl-2 expression