Nutchey et al., Biochem J 2005
:
Using HEK-293T cells ( human embryonic kidney 293T cells ), we reported that 1,25D induction of CYP24 requires JNK ( c-Jun N-terminal kinase ) but not the ERK1/2 ( extracellular-signal regulated kinase 1/2 )
Cui et al., J Cell Physiol 2009
(MAP Kinase Signaling System) :
This suggests ERK1/2 signaling enhances 1,25 ( OH ) ( 2 ) D ( 3 ) effects on the CYP24 promoter by MED1 mediated events