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EPHB2 — LOX

Text-mined interactions from Literome

Wu et al., Cancer Res 2007 (Lung Neoplasms...) : Ectopic Pro-LOX and LOX-PP expression in H1299 lung cancer cells inhibited growth in soft agar and invasive colony formation in Matrigel and reduced activation of extracellular signal regulated kinase ( ERK ) and Akt, with LOX-PP showing substantially higher activity ... Similarly, LOX-PP expression in PANC-1 pancreatic cancer cells effectively reduced ERK and Akt activity and inhibited growth in soft agar and ability of these cells to migrate
Agarwal et al., Exp Dermatol 2009 : Further, 12- ( R ) -HETE, 12- ( S ) -HETE and PGE ( 2 ) upregulated the p-ERK and p-Akt levels, suggesting the involvement of ERK and Akt pathways in the 12-LOX- and COX-2 mediated regulation of growth in A431 cells
Vora et al., J Biol Chem 2010 : Enzyme linked immunosorbent assay and Western blot analyses show that LOX-PP inhibits FGF-2 induced ERK1/2 phosphorylation, signaling events that mediate the FGF-2 induced proliferative response
Min et al., J Cell Biochem 2010 (Breast Neoplasms...) : In MIA PaCa-2 cells in culture, LOX-PP attenuated the ERK and AKT activities and decreased the levels of the NF-?B p65 and RelB subunits and cyclin D1, which are activated by RAS signaling
Voloshenyuk et al., Cytokine 2011 (MAP Kinase Signaling System) : The increase of LOX protein in response to TGF-ß1 was prevented by inhibitors of PI3K, Smad3, p38-MAPK, JNK and ERK1/2
Sato et al., Mol Cell Biol 2011 (Breast Neoplasms) : LOX-PP inhibits Erk signaling, motility, and tumor formation in a breast cancer xenograft model ; however, its mechanism of action is largely unknown
Garcia-Verdugo et al., Eur Respir J 2012 (MAP Kinase Signaling System) : 12-LOX inhibitors reduce ERK activation and Sp1 translocation induced by PMA