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BCL2 — PTEN

Text-mined interactions from Literome

Davies et al., Cancer Res 1999 (Carcinoma...) : Overexpression of Bcl-2 in LNCaP cells blocked MMAC/PTEN- and p53 induced apoptosis but not the growth-suppressive effects of MMAC/ PTEN, suggesting that the growth regulatory effects of MMAC/PTEN involve multiple pathways
Ghosh-Choudhury et al., Breast Cancer Res Treat 2009 (Adenocarcinoma...) : Finally, we showed that PTEN expression significantly inhibited NFkappaB dependent transcription of Bcl-2 and Bcl-XL genes
Singh et al., BMC cancer 2013 : In A2780 cells, restoration of PTEN levels was achieved upon pre-treatment with Z-DEVD-FMK ( broad range caspases inhibitor ) and not with MG132 ( proteasome inhibitor ) and by overexpression of BCL-2, suggesting that caspases and BCL-2 are involved in the decrease of PTEN protein levels in A2780 cells