Gene interactions and pathways from curated databases and text-mining

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JUN — NOTCH4

Text-mined interactions from Literome

Wu et al., Mol Cell Biol 2007 : The signal dependent transcription factor activator protein 1 (AP-1) activates Notch4 transcription in endothelial cells, but other factors/signals that regulate Notch4 are largely unknown
Henken et al., Cellular oncology (Dordrecht) 2012 (Cell Transformation, Neoplastic...) : Moderate Notch expression led to an increased AP-1 transcriptional activity and DNA binding activity, but did not affect complex composition
Yun et al., Oncogenesis 2013 : In conclusion, PKCa overexpression induces Notch-4 through AP-1
Ordentlich et al., Mol Cell Biol 1998 : We provide evidence that Notch and Deltex may act on E47 by inhibiting signaling through Ras because ( i ) full E47 activity was found to be dependent on Ras and ( ii ) both Notch and Deltex inhibited GAL4-Jun , a hybrid transcription factor whose activity is dependent on signaling from Ras to SAPK/JNK