Gene interactions and pathways from curated databases and text-mining

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CCK — JUN

Text-mined interactions from Literome

Gukovsky et al., Am J Physiol Gastrointest Liver Physiol 2003 (Pancreatitis, Alcoholic) : Curcumin also blocked CCK induced NF-kappaB and AP-1 activation in isolated pancreatic acini
Guo et al., Am J Physiol Gastrointest Liver Physiol 2012 : When signaling pathways were evaluated, CCK stimulation increased c-Jun expression, JNK and ERK activity, and AP-1 activation ... Chemical inhibitors of JNK and ERK pathways, dominant negative JNK and c-Jun, and c-Jun shRNA significantly inhibited CCK induced DNA synthesis, CCK induced AP-1 activation, and cyclin D1 expression
Oiry et al., Mol Pharmacol 1997 : To confirm that CCK ( B ) receptors are involved in AP-1 response, we investigated the CCK-8 effect on interleukin-2 expression, a natural endogenous gene regulated by several factors, including AP-1
Tateishi et al., Pancreas 1998 (Carcinoma, Ductal, Breast...) : c-Jun amino-terminal kinases (JNKs) of 46 kDa ( p46jnk ) and 55 kDa ( p55jnk ) were also activated by CCK-8 and increased the phosphorylation of c-Jun ... CCK-8 at 10 ( -7 ) M induced 1.5-fold increases in the phosphorylation of MAPK and of c-Jun by JNKs, respectively