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IL2 — TRAF6
Text-mined interactions from Literome
Lomaga et al., Genes Dev 1999
(Osteopetrosis) :
TRAF6 deficiency
results in osteopetrosis and defective
interleukin-1 , CD40, and LPS signaling
Greene et al., Biochim Biophys Acta 1999
:
Interleukin-1 receptor associated kinase and
TRAF-6 mediate the transcriptional regulation of
interleukin-2 by interleukin-1 via NFkappaB but unlike interleukin-1 are unable to stabilise interleukin-2 mRNA ... A dominant negative
TRAF-6 inhibited reporter gene expression and
interleukin-2 protein production in response to both interleukin-1 and IRAK transfection ... These data implicate IRAK and
TRAF-6 in transcriptional
regulation of
interleukin-2 gene expression via NFkappaB, and provide direct evidence that IRAK lies upstream from TRAF-6
Sun et al., Mol Cell 2004
(Lymphoma, B-Cell, Marginal Zone) :
RNAi mediated silencing of MALT1, TAK1,
TRAF6 , and TRAF2
suppressed TCR dependent IKK activation and
interleukin-2 production in T cells
Mason et al., Infect Immun 2004
:
TRAF6 dependent mitogen activated protein kinase activation differentially
regulates the production of
interleukin-12 by macrophages in response to Toxoplasma gondii
Frobøse et al., Mol Endocrinol 2006
:
Suppressor of cytokine Signaling-3
inhibits interleukin-1 signaling by targeting the
TRAF-6/TAK1 complex
King et al., J Immunol 2008
:
We have determined that the loss of
TRAF6 restores the ability of CD28-/- T cells to proliferate and produce
IL-2
Cejas et al., Blood 2010
:
TRAF6 inhibits Th17 differentiation and TGF-beta mediated suppression of
IL-2