◀ Back to CDKN1A
CDKN1A — TNF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Doman et al., J Interferon Cytokine Res 1999
:
TNF also
stimulated p53,
p21WAF1 , and Bax accumulation with subsequent PARP cleavage and nucleosomal DNA laddering in MCF-7 cells but did not stimulate these processes in MCF-7/3E9 cells
Javelaud et al., Oncogene 2000
(Sarcoma, Ewing) :
Induction of
p21Waf1/Cip1 by
TNFalpha requires NF-kappaB activity and antagonizes apoptosis in Ewing tumor cells
Kobayashi et al., Cytokine 2000
(Colonic Neoplasms) :
TNF-alpha induced
p21 ( WAF1 ) but not Bax in colon cancer cells WiDr with mutated p53 : important role of protein stabilization ...
TNF-alpha induced expression of
p21 ( WAF1 ) at protein and mRNA levels in a dose dependent fashion with an association with G ( 1 ) -arrest in human colon cancer cells WiDr that carry mutated p53 at codon 273 ( His ( 273 ) ) ... Co-transfection of the p53 His ( 273 ) expression construct with a luciferase gene controlled by the p21 ( WAF1 ) promoter showed that the p53 His ( 273 ) was inactive, although
TNF-alpha increased the transcriptional rate of
p21 ( WAF1 ) in these cells ... These findings suggest that
TNF-alpha induces expression of
p21 ( WAF1 ) through a distinct pathway from Bax and that protein stabilization is an important mechanism in the expression of p21 ( WAF1 ) independent of p53
Drané et al., Cell Death Differ 2002
:
In MCF-7 cells,
TNF alpha
induces a G1 arrest with an increased expression of
p21/Waf1 , an activation of NF-kappa B and an accumulation of p53
Kim et al., Carcinogenesis 2002
:
TNF-alpha potentiated the cadmium induced accumulation of p53 but did not
affect expression levels of Bax, Mdm2 and
p21 ( WAF/CIP )
Moneo et al., J Cell Biochem 2003
:
In these conditions the
TNF induced increase of
p21 ( waf1 ) is not sufficient to inhibit the high amount of cyclin D-bound complexes
Akca et al., Growth Factors 2003
(Uterine Cervical Neoplasms) :
We found that
TNF-alpha can
increase the cellular levels of p53,
p21 and induce apoptosis in ME180S cells ... An inhibitor of PKC, GF 109203X inhibited EGF mediated suppression of
TNF-alpha induced accumulation of p53,
p21 and induction of apoptosis
Chung et al., Mol Ther 2003
(Arthritis, Rheumatoid...) :
We found that the histone deacetylase (HDAC) inhibitors ( phenylbutyrate and trichostatin A ) causing histone hyperacetylation to modulate multiple gene expression not only induced the expression of
p21 ( Cip1 ) and p16(INK4) in synovial cells but also
inhibited the expression of
tumor necrosis factor-alpha in affected tissues in adjuvant arthritis, an animal model of RA
Beyne-Rauzy et al., Oncogene 2004
(Chromosomal Instability...) :
The present study described that, in the leukemic KG1 cells,
TNFalpha induced no apoptosis but a senescence state characterized by prolonged growth arrest, increased beta-galactosidase activity,
p21WAF-1 induction, decreased telomerase activity, telomeric disturbances ( shortening, losses, fusions ), and additional chromosomal aberrations
Kwak et al., Biochem Biophys Res Commun 2005
:
Tumor necrosis factor-alpha induces differentiation of human peripheral blood mononuclear cells into osteoclasts through the induction of
p21 ( WAF1/Cip1 )
Wang et al., Exp Cell Res 2005
:
TNF-alpha induced increases in
p21 expression resulting in partial cell cycle attenuation in the G1 phase
Wang et al., Clin Cancer Res 2005
(Breast Neoplasms...) :
Further investigation showed that silencing of hPEBP4 in MCF-7 cells promoted
TNF-alpha induced stability of p53, up-regulation of phospho-p53ser15,
p21waf/cip , and Bax, and down-regulation of Bcl-2 and Bcl-xL, which were shown to depend on extracellular signal regulated kinase 1/2 and c-jun NH2-terminal kinase activation by hPEBP4 silencing
Kokkinakis et al., Cancer Lett 2006
(Neoplasms) :
The response of tumors to MET-stress depends on their mutational status, however, it always involves inhibition of CDK1 and in most cases the upregulation of
p21 , p27, GADDs and 14-3-3sigma in
response to upregulation of TGF-beta, IRF-1,
TNF-alpha , Rb and/or MDA-7 and the downregulation of PI3K, RAS and NF-kappaB
Kumar et al., Molecular cancer 2007
(Brain Neoplasms...) :
TNF-alpha induced inhibition of proliferation and
enhanced the expression of
p21cip/waf1 and p27kip1 in LN-18 cells ... Spheroidogenesis enhanced p27 expression and
p21 induced by
TNF-alpha was significantly increased in the MCS compared to monolayers ... Our findings provide evidence that
TNF-alpha induced
p21 might be regulated by NF-kappaB or p53 independently
Spurling et al., Mol Carcinog 2008
(Adenocarcinoma...) :
RNAi induced reduction of HDAC3 in SW480 cells increased their constitutive, butyrate-, TSA-, and
TNF-alpha induced expression of
p21 , but did not cause all the gene expression changes induced upon general histone deacetylase (HDAC) inhibition
Flanagan et al., BMC cancer 2010
(Breast Neoplasms...) :
Over-expression of secretory clusterin also blocks the
TNFalpha mediated induction of
p21 and abrogates the cleavage of Bax to t-Bax, rendering the MCF-7CLU cells significantly more resistant to the cytokine than the parental cells
Yoshida et al., Int J Hematol 1996
:
Actinomycin D markedly inhibited
TNF-alpha induced
p21 mRNA expression, suggesting that the p21 gene is induced at the transcriptional level
Donato et al., J Biol Chem 1998
:
TNF was unable to
induce p21WAF1 in either cell line but affected the stability of this protein in apoptotically responsive ME-180S cells ... In addition,
TNF induced
p21WAF1 proteolysis may be mediated by an apoptotic protease and may contribute to the apoptotic process by disrupting p53 signaling, altering cell cycle inhibition, and limiting cellular recovery from genotoxic stress
Jiang et al., Biochem Biophys Res Commun 1998
(Breast Neoplasms) :
Prevention of
tumor necrosis factor (TNF) mediated induction of
p21WAF1/CIP1 sensitizes MCF-7 carcinoma cells to TNF induced apoptosis ...
p21 induction by > 0.5 ng/ml
TNF in MRC-5 and MCF-7 cells correlated with the inhibition of cell growth ... Thus,
TNF induced
p21 accompanied by growth arrest may counteract or delay TNF cytotoxicity in MCF-7 cells