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TP53 — TWIST1

Pathways - manually collected, often from reviews:

• BioCarta tumor suppressor arf inhibits ribosomal biogenesis: Twist (TWIST1) → p53 (TP53) (transcription, inhibits)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TWIST1 — TP53 (direct interaction, pull down) Shiota et al., Oncogene 2008*
• IRef Biogrid Interaction: TWIST1 — TP53 (physical association, affinity chromatography technology) Shiota et al., Oncogene 2008*
• IRef Biogrid Interaction: TWIST1 — TP53 (physical association, affinity chromatography technology) Piccinin et al., Cancer Cell 2012*
• IRef Intact Interaction: Complex of TP53-KAT2B-TWIST1 (association, anti tag coimmunoprecipitation) Shiota et al., Oncogene 2008*
• IRef Intact Interaction: TWIST1 — TP53 (direct interaction, pull down) Shiota et al., Oncogene 2008*
• IRef Intact Interaction: TWIST1 — TP53 (physical association, anti tag coimmunoprecipitation) Shiota et al., Oncogene 2008*
• IRef Intact Interaction: TWIST1 — TP53 (physical association, anti bait coimmunoprecipitation) Shiota et al., Oncogene 2008*
• IRef Intact Interaction: TWIST1 — TP53 (physical association, filter binding) Shiota et al., Oncogene 2008*
• IRef Intact Interaction: TWIST1 — TP53 (direct interaction, pull down) Piccinin et al., Cancer Cell 2012*
• IRef Intact Interaction: TWIST1 — TP53 (physical association, anti bait coimmunoprecipitation) Piccinin et al., Cancer Cell 2012*

Text-mined interactions from Literome

Maestro et al., Genes Dev 1999 (Cell Transformation, Neoplastic...) : Thus, Twist may affect p53 indirectly through modulation of the ARF/MDM2/p53 pathway
Vichalkovski et al., Oncogene 2010 (Neoplasms) : PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage
Kogan-Sakin et al., Cell Death Differ 2011 (Prostatic Neoplasms) : Mutant p53 ( R175H ) upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells ... The mechanism by which p53 ( R175H ) mutant induces Twist1 expression involves alleviation of the epigenetic repression
Hupp et al., Cancer Cell 2012 : In this issue of Cancer Cell, Piccinin and colleagues use this approach to demonstrate that the mesenchymal protein Twist1 inhibits p53 , providing a novel target for reactivation of p53 in human sarcoma