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FOXP3 — STAT3

Text-mined interactions from Literome

Yao et al., Blood 2007 : Reduction of Stat3 in T cells did not reduce the numbers of Treg cells in the thymus or spleen ; however, Stat3 was required for IL-6 dependent down-regulation of Foxp3
Yang et al., J Biol Chem 2007 (Inflammation) : Moreover, STAT3 regulated the expression of retinoic acid receptor related orphan receptor gamma-T ( RORgamma t ), a THi-specific transcriptional regulator ; STAT3 deficiency impaired RORgamma t expression and led to elevated expression of T-box expressed in T cells ( T-bet ) and Forkhead box P3 (Foxp3)
Wang et al., Cell Immunol 2007 : The role of STAT3 in antigen-IgG inducing regulatory CD4 ( + ) Foxp3 ( + ) T cells
Yang et al., Nat Immunol 2011 : Whereas STAT3 induced IL-17 and the transcription factor ROR?t and inhibited the transcription factor Foxp3 , IL-2 inhibited IL-17 independently of Foxp3 and ROR?t
Shen et al., PloS one 2012 (Carcinoma, Renal Cell...) : In vitro low dose entinostat ( 0.5 µM ) induced STAT3 acetylation and a specific inhibitor of STAT3 partially rescued entinostat induced down-regulation of Foxp3, suggesting that STAT3 signaling is involved in Foxp3 down-regulation by entinostat