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CCR4 — CXCR3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Rottman et al., Lab Invest 2001
(Psoriasis) :
Collectively, these data suggest that CXCR3 and
CCR4 may be involved in T lymphocyte trafficking to the psoriatic dermis and that
CXCR3 is selectively
involved in subsequent T cell homing to the overlying epidermis
Chiu et al., J Leukoc Biol 2002
:
CXCR3 and CCR6 transcripts were biased to type-1, and
CCR4 transcripts
increased in type-1 and type-2 populations
Moed et al., Clin Exp Allergy 2004
(Dermatitis, Allergic Contact) :
A second group of AID, which included VD ( 3 ), HC and DMF, suppressed mainly type-1 T cell responses, as revealed by strong interference with IFN-gamma production and
CXCR3 expression, and limited
effects on either or both IL-5 and
CCR4 expression
Chizzolini et al., Blood 2008
:
PGE ( 2 ) doubled the frequency of CD4+ T cells producing IL-17 and within the CD4+ subset
enhanced C-C chemokine receptor 6 (CCR6) and
CCR4 while decreasing
CXC chemokine receptor 3 (CXCR3) expression