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EPHB2 — PLG
Text-mined interactions from Literome
Webb et al., J Cell Biol 2001
(Breast Neoplasms) :
ERK phosphorylation was not
induced by tissue-type
plasminogen activator-PAI-1 complex or by uPA-PAI-1 complex in the presence of antibodies that block uPA binding to uPAR
Liu et al., Cancer Cell 2002
(Carcinoma, Hepatocellular...) :
Urokinase
plasminogen activator receptor ( uPAR )
activates alpha5beta1 integrin and
ERK signaling, inducing in vivo proliferation of HEp3 human carcinoma
Maupas-Schwalm et al., FASEB J 2004
(MAP Kinase Signaling System) :
The sphingomyelin/ceramide pathway is involved in
ERK1/2 phosphorylation, cell proliferation, and uPAR overexpression
induced by tissue-type
plasminogen activator
Zhang et al., J Am Soc Nephrol 2007
(Disease Models, Animal...) :
Both
plasmin induced
ERK activation and EMT were significantly blocked in vitro by the protease activated receptor-1 (PAR-1) silencing RNA ; by pepducin, a specific anti-PAR-1 signaling peptide ; and by the ERK kinase inhibitor UO126
Huang et al., Kidney Int 2007
:
An
ERK kinase inhibitor significantly
reduced the renin induced ERK1/2 phosphorylation and the subsequent increase in transforming growth factor-beta1 ( TGF-beta1 ) and
plasminogen activator inhibitor-1 mRNA expression
Kawao et al., Biochim Biophys Acta 2007
(Carbon Tetrachloride Poisoning...) :
The
plasmin induced phosphorylation of
ERK1/2 was inhibited by the LBS inhibitor epsilon-aminocaproic acid ( EACA ), the serine protease inhibitor aprotinin, and the MEK inhibitor PD98059
Zhang et al., J Immunol 2007
:
Interaction of
plasmin with annexin A2
resulted in the stimulation of
ERK1/2 and p38 MAPK, cyclooxygenase-2, and PGE ( 2 ), leading to increased MMP-1 production
Li et al., Experimental biology and medicine (Maywood, N.J.) 2013
(Plaque, Atherosclerotic) :
Activation of HUVEC by
plasmin led to cleavage of the annexin A2 subunit of the receptor complex, followed by the activation of Akt/nuclear factor ( NF ) -?B signaling, and phosphorylation of MAP kinases p38 and
ERK1/2