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PRKAR2A — ZGLP1
Text-mined interactions from Literome
Reimer et al., Endocrinology 2001
:
Activators of
PKA and PKC were able to
increase GLP-1 secretion in NCI-H716 cells
Ni et al., J Biol Chem 2003
:
Although proglucagon transcription and
GLP-1 synthesis were shown to be
activated by forskolin and other
protein kinase A (PKA) activators, deleting or mutating the cAMP-response element ( CRE ) only moderately attenuates the proglucagon gene promoter in response to PKA activation
Ong et al., Br J Pharmacol 2009
:
A
role for intracellular
cAMP/PKA in enhancing
GLP-1 release in response to overexpression of D556A-PDE4D5 mutant was demonstrated by the finding that the PKA inhibitor H89 reduced both basal and glucose induced GLP-1 release by 37 % and 39 %, respectively, from C1 GLUTag cells
Dong et al., Am J Physiol Endocrinol Metab 2013
:
In cultured endothelial cells,
GLP-1 acutely
increased PKA activity and stimulated endothelial NO synthase phosphorylation at Ser ( 1177 ) and NO production
Luo et al., Int J Biochem Cell Biol 2013
(Second Messenger Systems) :
It is of note that
GLP-1 preferentially
increased the expression and activity of
PKA , whereas had no effects on Epac2 at high glucose
Moberly et al., Basic Res Cardiol 2013
(Diabetes Mellitus, Type 2...) :
No evidence for
GLP-1 mediated
activation of
cAMP/PKA or AMPK signaling in lean or obese hearts was observed