◀ Back to IGF1
IGF1 — INSR
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
INSR
→
Complex of IGF1-INSR
(increases, IGF1/INSR Activity)
Evidence: IGFs can also bind and activate the insulin receptor
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KEGG Aldosterone-regulated sodium reabsorption:
IGF1
→
INSR
(protein-protein, activation)
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WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway:
EFNA1/FGF1/FGF11/FGF10/EFNA2/EGF/FGF12/CSF1/ANGPT4/ANGPT2/ANGPT1/VEGFA/EFNA3/EFNA4/EFNA5/FGF14/FGF19/FGF17/FGF18/FGF2/FGF3/FGF4/FGF6/FGF7/FGF8/FGF9/FIGF/HGF/IGF1/INS/INS/KITLG/VEGFC/VEGFB/PDGFB/PGF/PDGFA/NGF/PDGFC/FGF21/FGF22/PDGFD/FGF20/FGF16
→
FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK
(activation)
Text-mined interactions from Literome
Pirskanen et al., Dev Biol 2000
:
RT-PCR analysis
detected insulin, IGF-II,
insulin receptor , and IGF receptor mRNAs in both the neural tube and the somites, whereas
IGF-I transcripts were detected in entire embryos but not in the neural tube or somites
Duronio et al., Biochem J 1990
:
The increase in phosphorylation of
insulin receptor in
response to
IGF-I correlated with the dose-response of IGF-I stimulated phosphorylation of the IGF-I receptor ... 4. The
IGF-I stimulated phosphorylation of the
insulin receptor could be blocked by preincubation with a monoclonal antibody that blocks IGF-I binding to the IGF-I receptor
Denley et al., Mol Cell Biol 2007
:
Differential
activation of
insulin receptor substrates 1 and 2 by
insulin-like growth factor activated insulin receptors
Barnes et al., Clin Cancer Res 2007
(Head and Neck Neoplasms) :
Pretreatment of serum starved 183A or TU159 SCCHN cell lines with A12 ( 10 microg/mL ) blocked
IGF stimulated activation of IGF-IR,
insulin receptor substrate (IRS)-1 and IRS-2, mitogen activated protein kinase, and phosphatidylinositol 3-kinase
Hasslacher et al., Exp Clin Endocrinol Diabetes 2010
(Diabetic Nephropathies) :
This might be due to a stimulating effect of insulin analogs on erythropoiesis via
IGF receptor or a sustained
activation of the
insulin receptor
Sugita et al., Mol Cancer Res 2010
(Neoplasm Invasiveness...) :
NO donor inhibited
insulin/IGF-I stimulated phosphorylation of
insulin receptor/IGF-I receptor, IRS-1, Akt/PKB, and glycogen synthase kinase-3beta along with decreased expression of IRS-1 protein in MIAPaCa-2 cells, whereas NO donor enhanced the phosphorylation of extracellular signal regulated kinase-1/2
Huang et al., J Biol Chem 2010
:
In addition to inhibiting insulin receptor and IGF1R kinase activity by directly binding to the receptors, GRB10 can also negatively
regulate insulin and
IGF1 signaling by mediating
insulin receptor and IGF1R degradation through ubiquitination
Cascieri et al., Diabetologia 1989
:
It has been shown that
insulin-like growth factor I stimulates the uptake and metabolism of glucose in muscle through the insulin-like growth factor receptor not the
insulin receptor
Foley et al., J Biol Chem 1982
(Chondrosarcoma...) :
Similarly, the
anti-insulin receptor IgG only partially
inhibited the binding of
125I-IGF-I and 125I-IGF-II while completely blocking the binding of 125I-insulin
Milasincic et al., Mol Cell Biol 1996
:
We further demonstrate that
IGF-1 is a potent
activator of both
insulin receptor substrate IRS-1 tyrosyl phosphorylation and association of IRS-1 with activated phosphatidylinositol 3-kinase ( PI 3-kinase )
Takata et al., Metabolism 1996
:
These results suggest that the Asp 1048 IR causes a dominant negative effect on
IGF-IR in transmitting signals to Shc and MAP kinase activation, which leads to decreased IGF-I stimulated DNA synthesis, and that the kinase-defective
insulin receptor does not
affect IGF-I stimulated IRS-I phosphorylation, which leads to the normal IGF-I stimulated glycogen synthesis
Conover et al., Exp Cell Res 1998
:
Insulin-like growth factor I induction of c-myc expression in bovine fibroblasts can be
blocked by antecedent
insulin receptor activation