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RNF43 — WNT2

Text-mined interactions from Literome

Koo et al., Nature 2012 (Adenoma...) : We conclude that RNF43 and ZNRF3 reduce Wnt signals by selectively ubiquitinating frizzled receptors, thereby targeting these Wnt receptors for degradation
Jiang et al., Proc Natl Acad Sci U S A 2013 (Carcinoma, Pancreatic Ductal...) : Here, we show that RNF43 inhibits Wnt/ß-catenin signaling by reducing the membrane level of Frizzled in pancreatic cancer cells, serving as a negative feedback mechanism