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IL12B — IL1B
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL12-mediated signaling events:
IL1 beta (IL1B)
→
IL12 complex (IL12A-IL12B)
(modification, activates)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL1 beta (IL1B)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, activates)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
Text-mined interactions from Literome
de Haan et al., Transplantation 2000
:
In this assay also the effects of anti-CD28 antibody and
interleukin- (IL) 1beta , IL-6, or
IL-12 mediated
costimulation on responder T cell proliferation and IL-2 production were investigated
Nakahara et al., Clin Exp Immunol 2005
(Neoplasms) :
However,
IL-1beta , but not IFN-gamma,
induced IL-12 p40 production by DCs without enhancing phenotypic maturation
Roggen et al., Toxicol Lett 2006
(Hypersensitivity) :
PGE ( 2 ) is synergistic with
IL-1beta and TNF-alpha in the induction of functional and phenotypic maturation of DC and
induce IL12 p40 production
Kidoya et al., J Immunol 2005
(Inflammation) :
IL-23 , which shares the p40 subunit with IL-12, but not IL-12 itself,
induced IL-17 production synergistically with
IL-1beta in resident PEC
Mpiga et al., Scand J Immunol 2006
(Chlamydia Infections) :
When infected HeLa cells were co-cultured with THP-1 cells, IL-6 and IL-8 secretion was sustained,
IL-1beta expression followed a bell shaped curve and IL-10,
IL-12p70 and TNF-alpha synthesis was down
regulated
Cho et al., J Immunol 2006
(Arthritis...) :
IL-1beta further
increased the production of
IL-23 , which induced IL-17 production and OX40 expression in splenic CD4 ( + ) T cells of IL-1Ra ( -/- ) mice
Liu et al., Rheumatology (Oxford) 2007
(Arthritis, Rheumatoid) :
To explore the source of the p19 subunit of interleukin-23 (IL-23) in joints with rheumatoid arthritis ( RA ), the
effects of
IL-1beta and tumour necrosis factor (TNF)-alpha on
IL-23 gene expression in RA fibroblast-like synoviocytes and the effect of IL-23 on proinflammatory cytokines
Cheung et al., J Immunol 2008
(Inflammation) :
IL-17A, IL-17F, and
IL-23 could
induce the release of chemokines GRO-alpha/CXCL1, IL-8/CXCL8, and MIP-1beta/CCL4 from eosinophils, while IL-17F and IL-23 could also increase the production of proinflammatory cytokines
IL-1beta and IL-6
Nold-Petry et al., J Biol Chem 2009
(MAP Kinase Signaling System) :
In addition, we silenced IL-18Ralpha with small interfering RNA in primary human blood cells and observed up to 4-fold increases in the secretion of lipopolysaccharide- and
IL-12/IL-18 induced
IL-1beta , IL-6, interferon-gamma, and CD40L
Zhang et al., Clin Neurol Neurosurg 2010
(Autoimmune Diseases...) :
IFNbeta inhibited
IL-1beta , IL-23 and transforming growth factor ( TGF ) -beta ( which induce Th17 cell differentiation ), and
induced IL-27,
IL-12p35 and IL-10 ( which suppress it ) in dendritic cells (DCs) and B-cells
Kato et al., Glycoconj J 2010
:
Engagement of SIGNR1 on PEMs with an anti-SIGNR1-specific rat IgM antibody, ERTR9,
induced production of
IL-12 and tumor necrosis factor (TNF)-alpha from PEMs, while secretion of IL-6 and
IL-1beta was not detected with the same treatment
Seitz et al., Eur J Immunol 1996
:
In contrast,
IL-12 stimulated the production of
IL-1 beta and MCP-1 in TNF-alpha stimulated MNC and inhibited IL-1ra synthesis in cytokine stimulated cells