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IFNG — PRM3

Text-mined interactions from Literome

Li et al., Am J Physiol 1999 (Lung Diseases) : In an effort to elucidate the mechanism of gene inactivation, we report in this study that cationic lipid-protamine-DNA ( LPD ) complexes, but not each component alone, can induce a high level of cytokine production, including interferon-gamma and tumor necrosis factor-alpha
Däubener et al., J Interferon Cytokine Res 1996 (Glioblastoma) : In this report, we show that the antagonistic effect of protamine on heparin mediated inhibition of IFN-gamma activity is mainly due to the capacity of protamine to enhance IFN-gamma activity ... We found that protamine enhances the capacity of IFN-gamma to inhibit the growth of different brain tumor cell lines, to induce indolamine 2, 3-dioxygenase activity, to induce toxoplasmostasis, and to induce MHC class II antigen expression in human glioblastoma cells and in human native fibroblasts ... We were able to demonstrate that IFN-gamma binds to protamine, and, therefore, we assume that the effect of protamine on IFN-gamma is due to a direct interaction between the two molecules