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CCND1 — KLF8

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events mediated by focal adhesion kinase: KLF8 (KLF8) → Cyclin D1 (CCND1) (transcription, activates) Fincham et al., EMBO J 2000*, Yamamoto et al., Cell Signal 2003*, Zhao et al., Mol Cell 2003*
  Evidence: reporter gene, physical interaction

Text-mined interactions from Literome

Zhao et al., Mol Cell 2003 : Transcription activation of cyclin D1 by FAK requires both Ets family and KLF8 factors in a temporally differential manner
Nandan et al., Oncogene 2004 (Cell Transformation, Neoplastic) : Lastly, KLF5 activates expression of cyclin D1
Urvalek et al., American journal of translational research 2011 : Finally, KLF8 mediated cyclin D1 protein expression and cell cycle progression were significantly decreased in the K93R and K95R but increased in the K93Q, K95Q, K67R or K67Q mutant ... Finally, KLF8 mediated cyclin D1 protein expression and cell cycle progression were significantly decreased in the K93R and K95R but increased in the K93Q, K95Q, K67R or K67Q mutant