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FOXP3 — NOTCH4
Text-mined interactions from Literome
Samon et al., Blood 2008
:
Here, we show that pharmacologic inhibition of
Notch signaling using gamma-secretase inhibitor (GSI) treatment
blocks ( 1 ) TGFbeta1 induced
Foxp3 expression, ( 2 ) the up-regulation of Foxp3-target genes, and ( 3 ) the ability to suppress naive T-cell proliferation ... Together, these findings indicate that the
Notch and TGFbeta signaling pathways cooperatively
regulate Foxp3 expression and regulatory T-cell maintenance both in vitro and in vivo
Ou-Yang et al., Mol Cell Biochem 2009
:
As transcription factor Foxp3 acts as a master molecule governing the development and function of Tregs, we investigated whether
Notch signaling might directly
regulate Foxp3 expression