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CXCL12 — EGFR

Text-mined interactions from Literome

Mascia et al., Am J Pathol 2003 (Dermatitis, Contact...) : Conversely, EGFR signaling blockade produces opposite effects, with increased CCL2, CCL5, and CXCL10, and reduced CXCL8 expression
Kodali et al., Cardiovasc Res 2006 (Atherosclerosis...) : Interestingly, by blocking the ligand binding domain of EGFR, we demonstrate that activation of EGFR by SDF-1 and eotaxin occurs through different cellular pathways
Pattarozzi et al., Mol Pharmacol 2008 (Breast Neoplasms) : 17beta-estradiol promotes breast cancer cell proliferation inducing stromal cell derived factor-1 mediated epidermal growth factor receptor transactivation : reversal by gefitinib pretreatment ... Indeed, both SDF-1 and E2 caused EGFR tyrosine phosphorylation
Kokovay et al., Cell stem cell 2010 : We show that SDF1 strongly upregulates EGFR and alpha6 integrin in activated type B and type C cells, enhancing their activated state and their ability to bind laminin in the vascular niche
Ovrevik et al., Eur Respir J 2011 : TACE/TGF-a/EGFR regulates CXCL8 in bronchial epithelial cells exposed to particulate matter components ... However, EGFR inhibition strongly reduced CXCL8 release induced by all test compounds and selected compounds increased EGFR phosphorylation
Smirnova et al., Am J Pathol 2011 (Carcinoma, Squamous Cell...) : Inhibition of tumor necrosis factor-a converting enzyme using TNF-a protease inhibitor-2 selectively inhibited CXCL12 induced invasion but not EGF induced invasion, consistent with CXCL12 activation of EGFR via release of EGFR ligands
Abhold et al., PloS one 2012 (Carcinoma, Squamous Cell...) : Activation of EGFR by the addition of EGF ligand or ectopic expression of EGFR in two established HNSCC cell lines ( UMSCC-22B and HN-1 ) resulted in the induction of CD44, BMI-1, Oct-4, NANOG, CXCR4, and SDF-1
Zhao et al., PloS one 2012 (MAP Kinase Signaling System) : Low concentration of CsA promoted the secretion of CXCL12, and recombinant human CXCL12 promoted the phosphorylation of EGFR in primary human trophoblast cells and choriocarcinoma cell line JEG-3 ... The inhibition of CXCL12 or CXCR4 by either neutralizing antibodies or small interfering RNA ( siRNA ) could completely block the CsA induced EGFR phosphorylation