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NR3C1 — SMARCA4

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: NR3C1 → Complex of NR3C1-SMARCA4 (directlyIncreases, NR3C1/SMARCA4 Activity) Marshall et al., J Biol Chem 2003*
  Evidence: In contrast, RB enhances association of the glucocorticoid receptor (GR) with either BRG1 or hBRM, thus resulting in increased GR activity (51-53). The association between BRG1 or hBRM and GR is known to be direct, and recruitment of SWI/SNF complexes to GR may actually stimulate displacement of GR from chromatin, allowing GR to return to the remodeled chromatin with additional transcription factors (30).
• OpenBEL Selventa BEL large corpus: NR3C1 → Complex of NR3C1-SMARCA4 (directlyIncreases, NR3C1/SMARCA4 Activity) Marshall et al., J Biol Chem 2003*
  Evidence: RB enhances association of the GR with either BRG1 or BRM, resulting in increased GR activity
• OpenBEL Selventa BEL large corpus: Complex of NR3C1-SMARCA4 → RB1 (increases) Marshall et al., J Biol Chem 2003*
  Evidence: In contrast, RB enhances association of the glucocorticoid receptor (GR) with either BRG1 or hBRM, thus resulting in increased GR activity (51-53). The association between BRG1 or hBRM and GR is known to be direct, and recruitment of SWI/SNF complexes to GR may actually stimulate displacement of GR from chromatin, allowing GR to return to the remodeled chromatin with additional transcription factors (30).
• OpenBEL Selventa BEL large corpus: Complex of NR3C1-SMARCA4 → RB1 (increases) Marshall et al., J Biol Chem 2003*
  Evidence: RB enhances association of the GR with either BRG1 or BRM, resulting in increased GR activity
• BioCarta chromatin remodeling by hswi/snf atp-dependent complexes: glucocorticoid/glucocorticoid receptor/glucocorticoid/glucocorticoid receptor complex (NR3C1) → hSWI/SNF complex (SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) (modification, collaborate)
  
• BioCarta chromatin remodeling by hswi/snf atp-dependent complexes: hSWI/SNF complex (SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) → glucocorticoid/glucocorticoid receptor/glucocorticoid/glucocorticoid receptor/hSWI/SNF complex (NR3C1-NF1) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: IFN-beta nucleosome complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) → TAFs/TF2A/TBP/TF2F/TF2B/TF2H/TF2E/RNA POL II complex (GTF2A1-NR3C1-GTF2F1-GTF2B-GTF3A-GTF2E1-POLR2A) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) → TAFs/TF2A/TBP/TF2F/TF2B/TF2H/TF2E/RNA POL II complex (GTF2A1-NR3C1-GTF2F1-GTF2B-GTF3A-GTF2E1-POLR2A) (modification, collaborate)
  
• BioCarta chromatin remodeling by hswi/snf atp-dependent complexes: NF1 → glucocorticoid/glucocorticoid receptor/glucocorticoid/glucocorticoid receptor/hSWI/SNF/NF1 complex (NR3C1-NF1-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) (modification, collaborate)
  
• BioCarta chromatin remodeling by hswi/snf atp-dependent complexes: glucocorticoid/glucocorticoid receptor/glucocorticoid/glucocorticoid receptor/hSWI/SNF complex (NR3C1-NF1) → glucocorticoid/glucocorticoid receptor/glucocorticoid/glucocorticoid receptor/hSWI/SNF/NF1 complex (NR3C1-NF1-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) (modification, collaborate)
  
• BioCarta chromatin remodeling by hswi/snf atp-dependent complexes: glucocorticoid/glucocorticoid receptor/glucocorticoid/glucocorticoid receptor/hSWI/SNF/NF1 complex (NR3C1-NF1-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) → TAFs/TF2A/TBP/TF2F/TF2B/TF2H/TF2E/RNA POL II complex (GTF2A1-NR3C1-GTF2F1-GTF2B-GTF3A-GTF2E1-POLR2A) (modification, activates)
  
• NCI Pathway Database Glucocorticoid receptor regulatory network: cortisol/GR alpha (dimer) complex (NR3C1) → cortisol/GR alpha/BRG1/BAF155/BAF170/BAF60A complex (NR3C1-SMARCD1-SMARCA4-SMARCC2-SMARCC1) (transcription, inhibits)
  Kino et al., Mol Endocrinol 2007
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Glucocorticoid receptor regulatory network: nucleus (EP300/CREBBP) → cortisol/GR alpha/BRG1/BAF155/BAF170/BAF60A complex (NR3C1-SMARCD1-SMARCA4-SMARCC2-SMARCC1) (transcription, activates)
  Kino et al., Mol Endocrinol 2007
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Glucocorticoid receptor regulatory network: cortisol/GR alpha/BRG1/BAF155/BAF170/BAF60A complex (NR3C1-SMARCD1-SMARCA4-SMARCC2-SMARCC1) → SGK1 (SGK1) (transcription, activates) Kino et al., Mol Endocrinol 2007
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Glucocorticoid receptor regulatory network: BRG1/BAF155/BAF170/BAF60A complex (SMARCA4-SMARCC1-SMARCC2-SMARCD1) → cortisol/GR alpha (dimer) complex (NR3C1) (modification, collaborate)
  Hsiao et al., Mol Cell Biol 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Glucocorticoid receptor regulatory network: BRG1/BAF155/BAF170/BAF60A complex (SMARCA4-SMARCC1-SMARCC2-SMARCD1) → cortisol/GR alpha/BRG1/BAF155/BAF170/BAF60A complex (NR3C1-SMARCD1-SMARCA4-SMARCC2-SMARCC1) (modification, collaborate)
  Hsiao et al., Mol Cell Biol 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Glucocorticoid receptor regulatory network: cortisol/GR alpha (dimer) complex (NR3C1) → cortisol/GR alpha/BRG1/BAF155/BAF170/BAF60A complex (NR3C1-SMARCD1-SMARCA4-SMARCC2-SMARCC1) (modification, collaborate)
  Hsiao et al., Mol Cell Biol 2003
  Evidence: mutant phenotype, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SMARCA4 — NR3C1 (direct interaction, pull down) Wallberg et al., Mol Cell Biol 2000*
• IRef Biogrid Interaction: SMARCA4 — NR3C1 (physical association, affinity chromatography technology) Hsiao et al., Mol Cell Biol 2003
• IRef Biogrid Interaction: SMARCA4 — NR3C1 (colocalization, biochemical) Reyes et al., J Cell Biol 1997*
• IRef Biogrid Interaction: SMARCA4 — NR3C1 (physical association, affinity chromatography technology) Xu et al., J Biol Chem 2007*
• IRef Hprd Interaction: SMARCA4 — NR3C1 (in vitro) Fryer et al., Nature 1998*
• IRef Intact Interaction: NR3C1 — SMARCA4 (physical association, coimmunoprecipitation) Fryer et al., Nature 1998*