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GNRH1 — HSPG2

Text-mined interactions from Literome

Everest et al., Endocrinology 2001 (Breast Neoplasms) : Most extrapituitary GnRH-Rs have low affinity for GnRH analogs and may not activate PLC or discriminate between agonists and antagonists in the same way as pituitary GnRH-Rs
Kreda et al., Endocrinology 2001 : A dissection of the contributions of the phospholipases to LHRH secretion suggests that cPLA(2) acts downstream of PLC and that it significantly augments the PLC stimulated LHRH secretory response
Hsieh et al., Mol Endocrinol 1992 : In addition, the immunoglobulin G fraction of Gq/11 alpha peptide immune serum specifically inhibited TRH- and GnRH stimulated PLC activity measured in the membranes of GH3 and alpha T3-1 cells, respectively ... The results indicate that TRH and GnRH activation of PLC requires receptor coupling to a Gp protein ( s ) which corresponds to Gq, G11 or both
Negro-Vilar et al., Endocrinology 1986 : Phospholipase C (PLC) increased both PGE2 and LHRH secretion ... DiC10, PDBu, and PLC significantly augmented LHRH secretion from tissues in which metabolism of arachidonic acid had been prevented by inhibition of both cyclooxygenase and lipoxygenase pathways, suggesting that activation of protein kinase C, independent of PLA2 activation, can lead to the secretion of this neural peptide
Poulin et al., Mol Cell Endocrinol 1996 : In contrast to GnRH induced PLC activity, the PLA2 and PLD stimulation by the neuropeptide involved Ca2+ mobilization via VSCC activation ... This negative feed-back of PKC on GnRH Induced PLC and PLA2 activities was reversed when PKC was either down regulated after long TPA treatments or inhibited by the PKC inhibitors, staurosporine or GF109203X
Rabadan-Diehl et al., Endocrinology 1998 : Dexamethasone potentiated the stimulation of IP by other PLC dependent ligands ( GnRH , TRH ) but not that by the calcium ionophore, ionomycin, suggesting a site of action between the receptor and PLC
Poulin et al., Mol Cell Endocrinol 1998 : We studied in a gonadotrope cell line ( alphaT3-1 ) the effects of short as well as long term GnRH pretreatments on the GnRH induced phospholipases-C (PLC) , -A2 ( PLA2 ) and -D ( PLD ) activities, by measuring the production of IP3, total inositol phosphates ( IPs ), arachidonic acid ( AA ) and phosphatidylethanol ( PEt ) respectively