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BCL3 — PDLIM7

Text-mined interactions from Literome

Nakamura et al., Virus Res 2008 : The latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus induces expression of the putative oncogene Bcl-3 through activation of the nuclear factor-kappaB ... This LMP1 induced Bcl-3 expression is considered to be mediated by the transcription factor NF-kappaB, because ( 1 ) deletion of a critical NF-kappaB binding site in the Bcl-3 promoter abolished its responsiveness to LMP1, ( 2 ) an IkappaB mutant that specifically inhibits NF-kappaB activity suppressed the LMP1 induced activation of the Bcl-3 promoter, and ( 3 ) an LMP1 mutant lacking its effector domain CTAR2, required for the activation of NF-kappaB, is severely impaired in its ability to induce Bcl-3
Kung et al., J Virol 2008 : In addition to activating the canonical and noncanonical pathways, LMP1-CTAR1 constitutively activates STAT3 and increases Bcl-3
Kung et al., J Virol 2011 : EGFR transcription is induced by LMP1 through a p50 NF?B1-Bcl-3 complex, and Bcl-3 is induced by LMP1 mediated activation of STAT3
Inoue et al., Nihon rinsho. Japanese journal of clinical medicine 1997 : However, regulation of the Bcl-xL , Cdk4 and 6 and p27kip-1 expression by LMP1 and the molecular mechanism of LMP1 mediated B cell transformation remain to be elucidated