◀ Back to STAT1

MMP9 — STAT1

Text-mined interactions from Literome

Ma et al., J Immunol 2001 : IFN-gamma- and IFN-beta mediated inhibition of MMP-9 gene expression is dependent on the transcription factor STAT-1alpha , since IFN-gamma and IFN-beta fail to suppress MMP-9 expression in STAT-1alpha-deficient primary astrocytes and human fibrosarcoma cells
Zhou et al., J Biol Chem 2003 : Moreover, the phosphorylation of STAT1 by IFNgamma was blocked by an inhibitor of caspase 8, indicating that STAT1 had a suppressive effect on MMP-9
Klampfer et al., Cancer Res 2007 (Colorectal Neoplasms) : Despite the fact that silencing of STAT1 was not sufficient to alter the MMP , STAT1 deficiency, like Ras mutations, sensitized cells to apoptosis induced by HDACi
Gorina et al., Glia 2011 : Interplay between these signals was evidenced by the increased induction of MMP-9 in Stat1-deficient cells challenged with LPS, suggesting that Stat1 negatively regulates the expression of MMP-9 induced by LPS