Gene interactions and pathways from curated databases and text-mining

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PIP5K1C — RAC1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: PIP5K1C → RAC1 (increases, PIP5K1C Activity)
    Evidence: Studies in human T cells show that both RAC1 and RHOA are required to transduce chemokine receptor signals to the activation of LFA1 by phospholipase D and PIP5K1gamma106 (Fig. 5).
  • KEGG Fc gamma R-mediated phagocytosis: RAC1/RAC2 → PIP5K1A/PIP5K1B/PIP5K1C (protein-protein, activation)