◀ Back to EGF
EGF — YWHAB
Text-mined interactions from Literome
Antonelli et al., Mol Biol Cell 2000
:
In Chinese hamster ovary cells,
EGF receptors
activate B-Raf but not Raf-1 or A-Raf
Guan et al., J Biol Chem 2000
:
Furthermore, expression of Akt inhibits
epidermal growth factor induced
B-Raf activity and inhibition of Akt with LY294002 up-regulates B-Raf activity, suggesting that Akt negatively regulates B-Raf in vivo
Piiper et al., Mol Pharmacol 2000
:
In contrast, PTx, CCK, and
EGF had only minor effects on A-Raf and
B-Raf activity
Ren et al., Proc Natl Acad Sci U S A 2007
:
Our data identify a previously unrecognized interaction between IQGAP1 and B-Raf and suggest that IQGAP1 is a scaffold necessary for
activation of
B-Raf by
EGF
Yamaguchi et al., American journal of physiology. Renal physiology 2010
(Polycystic Kidney, Autosomal Dominant) :
We found that nanomolar concentrations of Sorafenib reduced the basal activity of ERK,
inhibited cAMP dependent activation of
B-Raf and MEK/ERK signaling, and caused a concentration dependent inhibition of cell proliferation induced by cAMP,
epidermal growth factor , or the combination of the two agonists