Gene interactions and pathways from curated databases and text-mining

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PPP1R14A — PRKCA

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: PPP1R14A → PRKCA (directlyIncreases, PPP1R14A Activity)
    Evidence: 12030846;11287002;12604330;15184667;15665049;15003508

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Patil et al., Am J Physiol Gastrointest Liver Physiol 2006 : Inhibition of PKCs or calphostin C or selective inhibition of PKC-alpha by negative dominant constructs inhibited phosphorylation of MYPT and CPI-17
Obara et al., Eur J Pharmacol 2008 : These results suggest that okadaic acid 's relaxant effect involves MLC(20) triphosphorylation through a direct phosphorylation by PKCalpha and an indirect phosphorylation by inhibition of myosin light chain phosphatase through PKCalpha mediated CPI-17 phosphorylation
Xu et al., Shock 2010 (Shock, Hemorrhagic) : Involvement of Cpi-17 and zipper interacting protein kinase in the regulation of protein kinase C-alpha , protein kinase C-epsilon on vascular calcium sensitivity after hemorrhagic shock ... In hypoxia treated vascular smooth muscle cells ( VSMCs ), the effects of PKC-alpha and PKC-epsilon agonists on protein expression and activity of CPI-17 and ZIPK and the modulating effects of CPI-17 and ZIPK on the regulation of PKC-alpha and PKC-epsilon on the activity of myosin light chain phosphatase ( MLCP ) were observed