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PPP1R14A — PRKCA
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
PPP1R14A
→
PRKCA
(directlyIncreases, PPP1R14A Activity)
Evidence: 12030846;11287002;12604330;15184667;15665049;15003508
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Patil et al., Am J Physiol Gastrointest Liver Physiol 2006
:
Inhibition of PKCs or calphostin C or selective inhibition of
PKC-alpha by negative dominant constructs
inhibited phosphorylation of MYPT and
CPI-17
Obara et al., Eur J Pharmacol 2008
:
These results suggest that okadaic acid 's relaxant effect involves MLC(20) triphosphorylation through a direct phosphorylation by PKCalpha and an indirect phosphorylation by inhibition of myosin light chain phosphatase through
PKCalpha mediated
CPI-17 phosphorylation
Xu et al., Shock 2010
(Shock, Hemorrhagic) :
Involvement of
Cpi-17 and zipper interacting protein kinase in the regulation of
protein kinase C-alpha , protein kinase C-epsilon on vascular calcium sensitivity after hemorrhagic shock ... In hypoxia treated vascular smooth muscle cells ( VSMCs ), the effects of PKC-alpha and PKC-epsilon agonists on protein expression and activity of
CPI-17 and ZIPK and the modulating
effects of CPI-17 and ZIPK on the regulation of
PKC-alpha and PKC-epsilon on the activity of myosin light chain phosphatase ( MLCP ) were observed