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FOXO3 — TRIM63

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TRIM63 → FOXO3 (increases, TRIM63 Activity)
  Evidence: the FOXO transcription factors and muscle atrophy the FOXO family of transcription factors was reported to regulate MAFbx and MuRF1 transcription and to influence muscle atrophy

Text-mined interactions from Literome

Senf et al., FASEB J 2008 (Muscular Atrophy) : Indeed, we show that specific inhibition of Foxo3a prevented the increases in both atrogin-1 and MuRF1 promoter activities during disuse
Senf et al., Am J Physiol Cell Physiol 2010 (Muscular Atrophy) : Specifically, Hsp70 inhibited FOXO3a induced promoter activation of atrogin-1, but not MuRF1 ... Further studies showed that a FOXO3a DNA binding mutant can activate MuRF1 , but not atrogin-1, suggesting that FOXO3a activates these two genes through differential mechanisms
Reed et al., FASEB J 2012 (Cachexia...) : Expression of DN FoxO inhibited the increased mRNA levels of atrogin-1, MuRF1 , cathepsin L, and/or Bnip3 and inhibited muscle fiber atrophy during cancer cachexia and sepsis
Murray et al., FASEB J 2013 : ROS activation of FoxO and NF-?B and their downstream targets, atrogin-1 and MuRF1 , was observed in M-ERR? ( -/- ) myocytes