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ELN — TGFB1

Text-mined interactions from Literome

Zhu et al., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2003 : This study was conducted to examine the effectiveness of a gene transfer of human TGF beta 1 gene into smooth muscle cells and whether the TGF beta 1 can increase elastin expression of smooth muscle cells
McGowan et al., Am J Physiol 1992 : Previous investigations suggested that transforming growth factor-beta ( TGF-beta ) increases elastin production by neonatal rat lung fibroblasts ( LF )
Sales et al., Circulation 2006 : Strong expression of tropoelastin was observed in response to TGF-beta1 equal to that in the unstimulated EPC
Macauley et al., Wound Repair Regen 1996 : We examined the effect of transforming growth factor-beta1 on the steady-state messenger RNA levels of elastin , alpha2 ( l ) procollagen, and lysyl oxidase ( the enzyme that cross-links both of these structural proteins ) in cell cultures of diploid human fibroblasts established from fetal skin, newborn foreskin, and an adult laryngeal stenotic lesion ... Inhibition of mRNA synthesis by actinomycin D showed that transcription was required for transforming growth factor-beta1 induction of elastin , alpha2 ( l ) procollagen, and lysyl oxidase mRNA in all three cultures of fibroblasts ... These results show that transforming growth factor-beta1 coordinately increases mRNA levels for the structural extracellular matrix proteins collagen and elastin , as well as for the cross linking enzyme, lysyl oxidase
Kuang et al., Am J Physiol Lung Cell Mol Physiol 2007 : Activation of elastin transcription by transforming growth factor-beta in human lung fibroblasts
Luo et al., Tissue Eng 2006 : TGF-beta1 induced matrix contraction and enhanced collagen and sulfated glycosaminoglycan production, bFGF effectively increased cell proliferation, and HGF stimulated synthesis of hyaluronic acid and elastin with less collagen accumulation than other conditions
Kothapalli et al., Tissue Eng Part A 2009 (Aortic Aneurysm) : While hyaluronan oligomers alone significantly suppressed aneurysmal cell proliferation and promoted 20-50 % increases in collagen and elastin synthesis ( p < 0.01 ), transforming growth factor-beta1 alone had no effect on cellular proliferation and elastin synthesis
Choi et al., Photochem Photobiol 2009 : Involvement of reactive oxygen species in TGF-beta1 induced tropoelastin expression by human dermal fibroblasts ... Transforming growth factor-beta1 ( TGF-beta1 ) stimulates synthesis of elastin by dermal fibroblasts and may mediate the increase in elastin in chronically photodamaged skin ... We investigated pathways involved in the TGF-beta1 induced increase in tropoelastin (TE) , the soluble elastin monomer and assessed the role of reactive oxygen species ( ROS ) in the regulation of TE mRNA
Liu et al., Biochem Biophys Res Commun 1988 : In the present study, by use of an Enzyme Linked Immunoassay method, we found that transforming growth factor-beta strongly increased elastin production in cultured porcine aortic smooth muscle cells
Davidson et al., J Cell Physiol 1993 : Modulation of transforming growth factor-beta 1 stimulated elastin and collagen production and proliferation in porcine vascular smooth muscle cells and skin fibroblasts by basic fibroblast growth factor, transforming growth factor-alpha, and insulin-like growth factor-I
Tajima et al., Arch Dermatol Res 1996 : Upregulation of elastin expression by transforming growth factor beta 1 was greater in the upper dermal fibroblasts than in the middle and lower dermal fibroblasts
Yamamoto et al., Stroke 1997 (Moyamoya Disease) : Although transforming growth factor-beta 1 ( TGF-beta 1 ), a potent enhancer of the expression of elastin in arterial SMCs, upregulated elastin mRNA and protein levels in SMCs from both moyamoya patients and control subjects, the maximum levels of elastin synthesis and elastin gene transcripts in response to exogenous TGF-beta 1 were significantly greater in moyamoya SMCs than control SMCs
Sauvage et al., Cell Tissue Res 1998 : The demonstration that TGF-beta1 immunoreactivity is present at the sites of elastin synthesis in the thoracic aorta and in the caudal artery and the observation that TGF-beta1 induces an increase in elastin mRNA levels in cultured endothelial cells and smooth muscle cells suggest that TGF-beta1 may be implicated, at least in part, in the physiological regulation of elastin gene expression
Yamamoto et al., Cell Biol Int 1997 (Uterine Prolapse) : Although transforming growth factor beta 1 ( TGF-beta 1 ) promoted elastin mRNA and protein levels in fibroblasts from both prolapsus uteri and control patients, the maximum levels of elastin gene transcripts and elastin synthesis in response to exogenous TGF-beta 1 were significantly lower in prolapsus uteri fibroblasts than control fibroblasts
Ahmed et al., Connect Tissue Res 1998 : These results combined with previous findings on elastin regulation by TGF-beta1 ( Kucich et al. ( 1997 )