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CD38 — IL4
Text-mined interactions from Literome
Levesque et al., Leuk Res 2006
(Leukemia, Lymphocytic, Chronic, B-Cell) :
IL-4 and IFN-gamma
regulate B cell
CD38 expression and NOS2 expression
Rousset et al., J Immunol 1988
(Burkitt Lymphoma) :
In addition, the expression of class I MHC Ag, the transferrin receptor,
CD38 , CD25, CD10, CD20, and CD21 were not
affected by
IL-4
Snoeck et al., Exp Hematol 1993
:
Differential
regulation of the expression of
CD38 and human leukocyte antigen-DR on CD34+ hematopoietic progenitor cells by
interleukin-4 and interferon-gamma ... We studied the
effects of
interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) on the expression of
CD38 and human leukocyte antigen ( HLA ) -DR on purified CD34+ bone marrow progenitor cells
Shubinsky et al., Cell Immunol 1996
:
The inhibition of protein synthesis with cycloheximide ( CXM ) diminished the down-regulation of
CD38 induced by
IL4 ... Staurosporine, an inhibitor of serine/threonine protein kinases, and H7 ( 1- ( 5-isoquinolinylsulfonyl ) -2-methylpiperazine ), a preferential inhibitor of protein kinase C ( PKC ), abrogated the
effect of
IL4 on
CD38 , while inhibitors of other serine protein kinases W7 ( N- ( aminohexyl ) -5-chloro-1-naphthalenesulfoamide ) and H8 ( N- ( 2- [ methylamino ] ethyl ) -5-isoquinolinesulfonamide ) failed to interfere with the effect of IL4 ... Genistein, an inhibitor of tyrosine kinases, increased the expression of CD38, but failed to abrogate the inhibitory
effect of
IL4 on
CD38 ... It is concluded that serine/threonine protein kinases mediated the
IL4 induced down-regulation of the expression of
CD38 molecules in B cells