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ESR2 — INS
Text-mined interactions from Literome
Wong et al., Proc Natl Acad Sci U S A 2010
:
Extranuclear
estrogen receptor-alpha stimulates NeuroD1 binding to the
insulin promoter and favors insulin synthesis
Richardson et al., Growth Factors 2011
(Breast Neoplasms) :
Insulin-like growth factor-2 (IGF-2) activates
estrogen receptor-a and -ß via the IGF-1 and the insulin receptors in breast cancer cells
Chaudhuri et al., Arch Surg 1986
(Diabetes Mellitus, Experimental...) :
To evaluate the effect of insulin on a receptor positive tumor, we examined the direct
effect of
insulin on an
estrogen receptor and its subsequent biologic effect on a receptor positive endometrial carcinoma model in vitro and in vivo
Siegel et al., Neuroendocrinology 1979
(Diabetes Mellitus, Experimental...) :
24 h
insulin deprivation
resulted in a signficant reduction of cell nuclear
estrogen receptor levels in hypothalamus-preoptic area of rats sacrificed 26 h after EB administration
Moore et al., J Biol Chem 1981
(Breast Neoplasms) :
An
insulin effect on cytoplasmic
estrogen receptor in the human breast cancer cell line MCF-7
Patrone et al., Mol Endocrinol 1996
(Neuroblastoma) :
These effects were shown to be due to an
insulin dependent activation of the unliganded
estrogen receptor ... The finding that, in neuroblastoma cells, selected signal transduction systems are involved in the
insulin dependent activation of
estrogen receptor is of particular interest considering that estrogen receptor might restrict the role played by insulin during the differentiation of neural cells and interfere with its proliferative potential while allowing its regulation of other functions related to cell survival