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IL1B — PTGS1

Text-mined interactions from Literome

Yucel-Lindberg et al., J Dent Res 1999 : Neither IL-1beta , TNFalpha, nor the combination of these two cytokines affected COX-1 mRNA levels
Strakova et al., Endocrinology 2000 : After 4 h of stimulation, IL-1beta induced gene expression of cyclooxygenase-2 (COX-2) but not cyclooxygenase-1 (COX-1)
Parfenova et al., Am J Physiol Cell Physiol 2001 : IL-1beta did not affect COX-1 expression, activity, and localization
Fan et al., J Gastroenterol Hepatol 2001 (Adenocarcinoma...) : In contrast, IL-1beta had no effect on the level of the constitutively expressed COX-1
Kol et al., Med Hypotheses 2002 : We have shown that IL-1 beta induces the in vitro expression of genes believed to play important role in ovulation ( IL-1 beta itself, its receptors, IL-1 beta receptor antagonist, glucose transporters 1 and 3, secretory and cytosolic phospholipase A ( 2 ), prostaglandin endoperoxide synthase 1 and 2 )
Kontny et al., Arthritis Rheum 2003 (Arthritis, Rheumatoid) : Upon stimulation with IL-1beta , elevation of COX-2, but not COX-1 , mRNA and protein preceded the enhancement of PGE ( 2 ) synthesis
Tsai et al., Int Immunopharmacol 2004 : Interleukin (IL)-1beta ( 25 ng/ml ), IL-8 ( 25 ng/ml ), growth related oncogene-alpha ( GRO, 50 ng/ml ) and tumor necrosis factor-alpha ( TNF-alpha, 25 ng/ml ) stimulated the COX-1 protein production as demonstrated by Western blot and enhanced PGE2 synthesis in GMC, beginning on 2 h of incubation, and steadily enhanced TXB2 synthesis over a 24-h period
Park et al., Int J Biochem Cell Biol 2004 (Bone Resorption) : However, neither IL-1beta , TNF-alpha, IL-6 nor a combination of IL-1beta, TNF-alpha, IL-6 enhanced COX-1 mRNA levels in calvarial osteoblasts
Machida et al., J Pharmacol Sci 2005 : DHA and eicosapentaenoic acid slightly enhanced IL-1beta induced cyclooxygenase (COX)-2, but not COX-1 , expression, whereas arachidonic acid had no effect
Chang et al., Int Endod J 2006 (Calcium Signaling...) : IL-1beta stimulated the COX-2 but not COX-1 mRNA expression
Solà-Villà et al., Kidney Int 2006 : No effect of IL-1beta on COX-1 , cytosolic PGES, or mPGES-2 expression was observed
Guo et al., Biol Pharm Bull 2006 : IL-1beta stimulation increased the protein, activity and mRNA expression of cyclooxygenase (COX)-2 but not COX-1
Seo et al., Biol Reprod 2012 : IL1B increased expression of PTGS1 and PTGS2 genes that are rate limiting for PG synthesis in the uterine endometrium ... Collectively, the results indicated that IL1B regulates expression of IL1R1 and IL1RAP and stimulates expression of PTGS1 and PTGS2 that are considered to be the most rate limiting enzymes for endometrial synthesis of PGs during the peri-implantation period of pregnancy in pigs
Jackson et al., Biochem Biophys Res Commun 1993 : Effects of transforming growth factor beta and interleukin-1 beta on expression of cyclooxygenase 1 and 2 and phospholipase A2 mRNA in lung fibroblasts and endothelial cells in culture
Roy et al., J Cell Biochem 1996 : Prostaglandin E2, transforming growth factor-beta, and interleukin-1 beta variably regulate the expression of cyclooxygenase 1 , cyclooxygenase 2, and lysyl oxidase in IMR90, human embryo lung fibroblasts
Diaz et al., Exp Cell Res 1998 : Analysis of fibroblast proteins showed the induction of cyclooxygenase-1 (Cox-1) by TGF-beta 1 and the induction of Cox-2 by IL-1 beta and TNF-alpha