◀ Back to IL1B
IL1B — MUC20
Text-mined interactions from Literome
Yoon et al., Acta Otolaryngol 1999
:
Effects of TNF-alpha and
IL-1 beta on
mucin , lysozyme, IL-6 and IL-8 in passage-2 normal human nasal epithelial cells ... The aim of this study was to examine whether TNF-alpha,
IL-1beta or their combination can
increase the secretion of
mucin as an indicator of mucous secretion, the secretion of lysozyme as an indicator of serous secretion and the secretion of IL-6 and IL-8 as important cytokines
Kim et al., Mol Pharmacol 2002
:
These results suggest a role for PGE ( 2 ) in
IL-1beta induced
mucin synthesis in NCI-H292 cells ... Furthermore, the addition of PGE ( 2 ) to cells overcame the inhibitory effects of both MAPK inhibitors in
IL-1beta induced
mucin production
Kim et al., J Korean Med Sci 2002
(MAP Kinase Signaling System) :
Interleukin-1beta induces MUC2 gene expression and
mucin secretion via activation of PKC-MEK/ERK, and PI3K in human airway epithelial cells ... This study was designed to investigate the signal transduction pathway of the
IL-1beta mediated MUC2 gene expression and
mucin secretion in human airway epithelial cells ... In cultured human airway NCI-H292 epithelial cells, the steady state of the mRNA level of MUC2 gene expression and
mucin secretion
induced by
IL-1beta were determined by reverse transcriptase-polymerase chain reaction ( RT-PCR ), enzyme immunoassay, and immunoblot analysis ... To observe the signal pathway of the
IL-1beta mediated MUC2 gene expression and
mucin secretion, we used several specific inhibitors ... PD98059 ( MEK/ERK inhibitor ) suppressed
IL-1beta mediated MUC2 gene expression and
mucin secretion, while SB203580 ( p38 inhibitor ) did not ... Ro31-8220 ( PKC inhibitor ) inhibited
IL-1beta mediated MUC2 gene expression and
mucin secretion ... These results suggest that the
IL-1beta mediated MUC2 gene expression and
mucin secretion in NCI-H292 cells are regulated through activation of the PKC-MEK/ERK pathway, and that PI3K is also involved in the IL-1beta mediated MUC2 gene expression and mucin secretion
Kerschner et al., Otolaryngol Head Neck Surg 2003
:
To investigate the
role of the inflammatory cytokine
interleukin-1beta (IL-1beta) in the regulation of
mucin secretion by middle ear epithelia ...
IL-1beta upregulates
mucin secretion from cultured middle ear epithelial cells in a dose- and time dependent manner
Gray et al., Mol Pharmacol 2004
:
Interleukin-1beta induced
mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling
Lappalainen et al., Am J Respir Cell Mol Biol 2005
(Asthma...) :
IL-1beta increased the thickness of conducting airways,
enhanced mucin production, and caused lymphocytic aggregates in the airways
Kerschner et al., Laryngoscope 2006
:
IL-1beta stimulates
mucin secretion from middle ear epithelium and its effects can be reversed by IL-1betara
Huang et al., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2010
:
These results suggest that
IL-1beta may
enhance mucin gene expression in cultured human nasal epithelial cells