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IL17D — IL1B

Text-mined interactions from Literome

Li et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010 : [ IL-27 regulates the expression of Mac-1, fMLP-R and IL-1beta in human neutrophils through p38 MAPK and PI3K signal pathways ] ... The present study was aimed to investigate the pathways, by which IL-27 regulates the expression of adherent molecule Mac-1, chemotactic factor receptor fMLP-R and pro-inflammatory cytokine IL-1beta in human neutrophils ... However, IL-27 up-regulated the mRNA expression of fMLP-R and IL-1beta , and increased the release of IL-1beta ( p < 0.05 ) ... It is concluded that the IL-27 may regulate the expression of Mac-1, fMLP-R and IL-1beta in human neutrophils through p38 MAPK and PI3K signal pathways
Zhang et al., Clin Neurol Neurosurg 2010 (Autoimmune Diseases...) : IFNbeta inhibited IL-1beta , IL-23 and transforming growth factor ( TGF ) -beta ( which induce Th17 cell differentiation ), and induced IL-27 , IL-12p35 and IL-10 ( which suppress it ) in dendritic cells (DCs) and B-cells