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CALM3 — IL6
Text-mined interactions from Literome
Ito et al., J Biol Chem 1991
:
These results indicate that
calmodulin is
required for the
interleukin 1-enhanced synthesis of TIMP but it is a suppressor for the synthesis of proMMPs-1 and -3
Duits et al., Scand J Immunol 1991
:
Selective
enhancement of
Leu-CAM expression by
interleukin 6 during differentiation of human promonocytic U937 cells
Sugiyama et al., Clin Exp Immunol 2007
:
Because dendritic cells (DCs) orchestrate immune responses, we examined the in vitro
effects of
clarithromycin (CAM) , azithromycin ( AZM ) and midecamycin ( MDM ) on the expression of co-stimulatory molecules and production of cytokines
[interleukin (IL)-10, IL-6, interferon (IFN)-gamma, IL-12p40, tumour necrosis factor (TNF)-alpha ] of murine bone marrow derived DCs by lipopolysaccharide (LPS) stimulation
Sato et al., Prostaglandins Leukot Essent Fatty Acids 2007
:
After treatment with a nonselective cyclooxygenase (COX) inhibitor ( indomethacin ), a selective COX-2 inhibitor ( NS398 ), or an EP ( 2 ) /EP ( 4 ) receptor antagonist ( AH6809 ), the inhibitory
effect of
CAM and EM on LPS induced
IL-6 production was equalized
Nie et al., J Physiol Sci 2007
(Calcium Signaling...) :
In this study, we investigated the
effects of
CaM and CaMKII inhibitors on
CDF and CDI with patch clamp cell attached recordings in guinea-pig ventricular myocytes
Findeisen et al., Structure 2010
(Ion Channel Gating) :
Furthermore, CaBP1 mediated CDF has different molecular requirements than
CaM mediated
CDF
Christel et al., Biochim Biophys Acta 2012
(Calcium Signaling) :
Tremendous progress has been made in characterizing the
role of
CaM in CDI and
CDF
Yokota et al., Mediators Inflamm 2012
(Respiratory Syncytial Virus Infections) :
Clarithromycin (CAM) , which is an antimicrobial agent and is also known as an immunomodulator, significantly
suppressed RSV induced production of interleukin-6,
interleukin-8 , and regulated on activation, normal T-cell expressed and secreted ( RANTES )
Cai et al., Immunobiology 2013
(Cryptogenic Organizing Pneumonia) :
CAM and AZM
induced a dose dependent suppression of spontaneous TNF-a, sTNFR2,
IL-6 , IL-8 and CCL18 production ( p < 0.05 ) ...
CAM also
inhibited the LPS stimulated TNF-a, IL-1ß,
IL-6 and IL-10 production
Shen et al., J Nutr 2013
(Inflammation...) :
U73122 attenuated 18 : 2t10, c12 mediated insulin resistance within 48 h and suppression of the mRNA levels of peroxisome proliferator activated receptor ( PPAR ) ?, insulin stimulated glucose transporter-4, acetyl-CoA carboxylase-1, and stearoyl-CoA desaturase-1, and the protein levels of PPAR? within 18-24 h. U73122 inhibited 18 : 2t10, c12 mediated induction of the inflammatory related genes
calcium/calmodulin dependent protein kinase-ß, cyclooxygenase-2, monocyte chemoattractant protein-1,
interleukin (IL)-6 , and IL-8, secretion of IL-6 and IL-8, and the activation of extracellular signal related kinase, c-Jun N-terminal kinase, and c-Jun within 18-24 h
Ojima et al., Biochim Biophys Acta 1989
:
Calmodulin regulates the
interleukin 1-induced procollagenase production in human uterine cervical fibroblasts
Takizawa et al., Biochem Biophys Res Commun 1995
:
Among those tested, erythromycin ( EM ) and
clarithromycin (CAM) uniquely
suppressed mRNA levels as well as the release of
IL-6 at the therapeutic and non-cytotoxic concentration ( 10 ( -6 ) M )