Gene interactions and pathways from curated databases and text-mining

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CALM3 — IL6

Text-mined interactions from Literome

Ito et al., J Biol Chem 1991 : These results indicate that calmodulin is required for the interleukin 1-enhanced synthesis of TIMP but it is a suppressor for the synthesis of proMMPs-1 and -3
Duits et al., Scand J Immunol 1991 : Selective enhancement of Leu-CAM expression by interleukin 6 during differentiation of human promonocytic U937 cells
Sugiyama et al., Clin Exp Immunol 2007 : Because dendritic cells (DCs) orchestrate immune responses, we examined the in vitro effects of clarithromycin (CAM) , azithromycin ( AZM ) and midecamycin ( MDM ) on the expression of co-stimulatory molecules and production of cytokines [interleukin (IL)-10, IL-6, interferon (IFN)-gamma, IL-12p40, tumour necrosis factor (TNF)-alpha ] of murine bone marrow derived DCs by lipopolysaccharide (LPS) stimulation
Sato et al., Prostaglandins Leukot Essent Fatty Acids 2007 : After treatment with a nonselective cyclooxygenase (COX) inhibitor ( indomethacin ), a selective COX-2 inhibitor ( NS398 ), or an EP ( 2 ) /EP ( 4 ) receptor antagonist ( AH6809 ), the inhibitory effect of CAM and EM on LPS induced IL-6 production was equalized
Nie et al., J Physiol Sci 2007 (Calcium Signaling...) : In this study, we investigated the effects of CaM and CaMKII inhibitors on CDF and CDI with patch clamp cell attached recordings in guinea-pig ventricular myocytes
Findeisen et al., Structure 2010 (Ion Channel Gating) : Furthermore, CaBP1 mediated CDF has different molecular requirements than CaM mediated CDF
Christel et al., Biochim Biophys Acta 2012 (Calcium Signaling) : Tremendous progress has been made in characterizing the role of CaM in CDI and CDF
Yokota et al., Mediators Inflamm 2012 (Respiratory Syncytial Virus Infections) : Clarithromycin (CAM) , which is an antimicrobial agent and is also known as an immunomodulator, significantly suppressed RSV induced production of interleukin-6, interleukin-8 , and regulated on activation, normal T-cell expressed and secreted ( RANTES )
Cai et al., Immunobiology 2013 (Cryptogenic Organizing Pneumonia) : CAM and AZM induced a dose dependent suppression of spontaneous TNF-a, sTNFR2, IL-6 , IL-8 and CCL18 production ( p < 0.05 ) ... CAM also inhibited the LPS stimulated TNF-a, IL-1ß, IL-6 and IL-10 production
Shen et al., J Nutr 2013 (Inflammation...) : U73122 attenuated 18 : 2t10, c12 mediated insulin resistance within 48 h and suppression of the mRNA levels of peroxisome proliferator activated receptor ( PPAR ) ?, insulin stimulated glucose transporter-4, acetyl-CoA carboxylase-1, and stearoyl-CoA desaturase-1, and the protein levels of PPAR? within 18-24 h. U73122 inhibited 18 : 2t10, c12 mediated induction of the inflammatory related genes calcium/calmodulin dependent protein kinase-ß, cyclooxygenase-2, monocyte chemoattractant protein-1, interleukin (IL)-6 , and IL-8, secretion of IL-6 and IL-8, and the activation of extracellular signal related kinase, c-Jun N-terminal kinase, and c-Jun within 18-24 h
Ojima et al., Biochim Biophys Acta 1989 : Calmodulin regulates the interleukin 1-induced procollagenase production in human uterine cervical fibroblasts
Takizawa et al., Biochem Biophys Res Commun 1995 : Among those tested, erythromycin ( EM ) and clarithromycin (CAM) uniquely suppressed mRNA levels as well as the release of IL-6 at the therapeutic and non-cytotoxic concentration ( 10 ( -6 ) M )