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FGF2 — S100B

Text-mined interactions from Literome

Riuzzi et al., J Cell Sci 2011 : Here, we show that S100B increases and/or stabilizes the binding of basic fibroblast growth factor (bFGF) to bFGF receptor 1 ( FGFR1 ) by interacting with bFGF, thereby enhancing FGFR1 activation and the mitogenic and anti-myogenic effects of FGFR1 ... However, when bound to S100B-bFGF-FGFR1, RAGE can no longer stimulate myogenic differentiation, whereas in the absence of either bFGF or FGFR1, binding of S100B to RAGE results in stimulation of RAGE anti-mitogenic and promyogenic signaling
Riuzzi et al., PloS one 2012 : In high-density myoblast cultures S100B enhances basic fibroblast growth factor (bFGF) receptor 1 ( FGFR1 ) signaling via binding to bFGF and blocks its canonical receptor, receptor for advanced glycation end-products ( RAGE ), thereby stimulating proliferation and inhibiting differentiation ... However, at relatively high doses, S100B stimulates the mitogenic bFGF/FGFR1 signaling in low-density myoblasts, provided bFGF is present