LeHoux et al., J Mol Endocrinol 2006
:
Overexpression of wild-type ERK1 and ERK2 significantly reduced basal as well as Ang II-stimulated human -2023CYP11B2-CAT activity ; conversely, the two dominant negative mutants increased them
Inagaki et al., Endocrinology 2006
(MAP Kinase Signaling System) :
The specific inhibitor of ERK activation, U0126, suppressed the activation of CYP11B2 transcription induced by BMP-6 without affecting Smad phosphorylation and Tlx2-Luc activity