McElvaney et al., J Clin Invest 1992
(Cystic Fibrosis...) :
Human bronchial epithelial cells exposed to CF ELF recovered before rSLPI therapy expressed IL-8 mRNA transcripts, but ELF recovered after rSLPI therapy induced far less bronchial epithelial cell IL-8 gene expression
Hedvat et al., J Biol Chem 2004
:
Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells
Nakamura et al., J Clin Invest 1992
(Cystic Fibrosis) :
CF ELF contained high levels of neutrophil elastase ( NE ) and various serine protease inhibitors prevented CF ELF from inducing IL-8 gene expression in BET-1A cells, suggesting that NE was the dominant inducer for IL-8 production in CF ELF