Luwor et al., Oncogene 2005
:
Pharmacologic inhibition of phosphatidylinositol 3-kinase with LY294002 reduced the HIF-1alpha level in both normoxic and hypoxic A431 cells, whereas inhibition of the mitogen activated protein kinase kinase by PD98059 reduced the level of HIF-1alpha only in normoxic A431 cells
Pi et al., Circ Res 2005
:
BMK1 activation by constitutively active ( CA ) -MEK5 inhibited HIF1alpha activity by 46+/-4 %, suggesting BMK1 functions as a negative regulator of HIF1alpha activation