Han et al., Biochem Biophys Res Commun 2008
:
These observations demonstrate that p300 can inactivate Sirt2 by acetylation and that p300 may regulate the activity of p53 indirectly through Sirt2 in addition to its direct modification of p53 van Leeuwen et al., Adv Cancer Res 2009
(Neoplasms) :
Preliminary observations also suggest that sirtuin mediated modulation of p53 can also take place indirectly through changes in cellular processes ( e.g., nucleolar function and p300 activity ) known to affect p53
Lynch et al., PloS one 2010
:
Thus, SIRT1 mediated inhibition of p53 has been identified as a key node in the common biology of cancer, metabolism, development and ageing
van Leeuwen et al., Mol Cancer Ther 2013
:
These results help understand why inhibition of both SirT1 and SirT2 is needed to achieve effective activation of p53 by small-molecule sirtuin inhibitors