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PTEN — TP53
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Stambolic et al., Mol Cell 2001
:
Regulation of
PTEN transcription by
p53 ... In contrast to p53 mutant cell lines, induction of
p53 in primary and tumor cell lines with wild-type p53
increased PTEN mRNA levels
Mayo et al., J Biol Chem 2002
(Glioblastoma...) :
p53 induces
PTEN gene expression, and here it is shown that PTEN protects p53, indicating that a positive feedback loop may amplify the cellular response to stress, damage, and cancer
Mayo et al., Trends Biochem Sci 2002
:
p53 acutely induces Mdm2, providing damaged cells the opportunity for repair, but subsequently
induces PTEN , favoring the death of mutated or irrevocably damaged cells
Freeman et al., Cancer Cell 2003
:
We show in this study that
PTEN regulates
p53 protein levels and transcriptional activity through both phosphatase dependent and -independent mechanisms ... Reintroducing wild-type or phosphatase-dead
PTEN mutants
leads to a significant increase in
p53 stability ... Finally,
PTEN regulates the transcriptional activity of
p53 by modulating its DNA binding activity
Hu et al., Cancer 2003
(Carcinoma, Hepatocellular...) :
Examining
p53 expression unveiled an inverse correlation between p53 overexpression and
reduced PTEN expression in patients with HCC ( P = 0.004 )
Chung et al., Cancer Res 2003
(Carcinoma, Hepatocellular...) :
However, we confirmed that the binding of the p53 protein to p53 binding site-oligo of PTEN promoter is decreased in HBx transfected liver cells by electrophoretic mobility shift analysis and, in addition, that HBx disrupts
p53 mediated
PTEN transcription, as evidenced by a PTEN promoter assay ... This constitutes the first report to demonstrate that HBx has an effect on the
p53 mediated transcription of
PTEN , which, in turn, is associated with tumor suppression
Zhou et al., Cancer Res 2003
(Burkitt Lymphoma...) :
Binding of
PTEN to p53
attenuated MDM2 mediated
p53 inhibition
Zhong et al., Zhonghua Zhong Liu Za Zhi 2003
(Astrocytoma) :
To study the incidence of PTEN, Mdm2 and p53 expression in different histopathological grades of astrocytoma and the signal transduction mechanism through which
PTEN affects Mdm2 and
p53 expression
Moon et al., Arch Biochem Biophys 2004
:
Such an arrest correlated with down-regulation of cyclins and CDKs and up-regulation of the CDK inhibitor p21 and p27 expression, whereas
up-regulation of
p53 by
PTEN expression was not observed
Mayo et al., J Biol Chem 2005
:
Induction of
PTEN by
p53 followed by expression of PTEN inhibits AKT induced translocation of MDM2 into the nucleus and sustains p53 function ... The protection of p53 from MDM2 by PTEN and the damage induced
activation of
PTEN by phosphorylated
p53 leads to the formation of an apoptotic amplification cycle in which p53 and PTEN coordinately increase cellular apoptosis
Wang et al., Cancer Res 2005
(MAP Kinase Signaling System) :
More importantly, deficiency of p53 expression resulted in a decrease in PTEN protein expression, suggesting that
p53 plays a critical role in the regulation of
PTEN expression
Tang et al., Cancer Res 2006
(Hamartoma Syndrome, Multiple...) :
We further show that
PTEN enhances
p53 transactivation, a relationship that requires the interaction between PTEN and p53 and is PTEN phosphatase independent
Yan et al., Gynecol Oncol 2006
(Ovarian Neoplasms) :
Whether
PTEN can facilitate cisplatin sensitivity, and this
involves the activation of
p53 , remains unclear
Li et al., Mol Cell 2006
:
Earlier studies have shown that
PTEN regulated
p53 protein stability both in a phosphatase dependent manner through antagonizing Akt-Mdm2 pathway and in a phosphatase independent manner through interacting with p53 ... Taken together, our results suggest a physiological role for the PTEN tumor suppressor in the nucleus and provide a molecular explanation for our previous observation that
PTEN controls
p53 protein levels independent of its phosphatase activity
Kim et al., Mol Cell Biol 2007
(Cell Transformation, Neoplastic) :
Stable depletion of
PTEN in untransformed human fibroblasts and epithelial cells also
led to upregulation of
p53 and senescence-like growth arrest
Feng et al., Cancer Res 2007
(Cell Transformation, Neoplastic) :
The
regulation of AMPK beta1, TSC2, and
PTEN expression by
p53 : stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
Selvendiran et al., J Biol Chem 2007
(Ovarian Neoplasms) :
Suppression of
PTEN expression with siRNA significantly
reduced the
p53 and p21 levels and activated Akt phosphorylation at Ser ( 473 ) and Thr ( 308 ), resulting in decreased apoptosis and increased cell survival
Escrivà et al., Mol Cell Biol 2008
(Pancreatic Neoplasms) :
The binding of Snail1 to the
PTEN promoter increases after gamma radiation, correlating with the stabilization of Snail1 protein, and
prevents the association of
p53 to the PTEN promoter
Hambardzumyan et al., Genes Dev 2008
(Brain Neoplasms...) :
Furthermore, the ability of these cells to induce
p53 is
dependent on the presence of
PTEN
Li et al., Cancer Res 2008
(Glioblastoma) :
We show the dependency of the tumor promoting
effects of
PTEN on
mut-p53 by showing that knockdown of mut-p53 expression inhibits or reverses the tumor promoting effects of PTEN ... Mechanistically, we show that
PTEN expression
enhances mut-p53 protein levels via inhibition of mut-p53 degradation by Mdm2 and possibly also via direct protein binding
Mitra et al., J Cell Mol Med 2009
(Graft Occlusion, Vascular...) :
However,
PTEN overexpression
had no significant effect on MDM2 and
p53 expression in IMA SMCs. PTEN overexpression inhibited IGF-1 induced SMC proliferation in both SV and IMA
Vella et al., Int J Cancer 2009
(Thyroid Neoplasms) :
PTEN expression is
increased by
p53 , and its function is blunted in several malignancies
Chen et al., Science signaling 2009
(Prostatic Neoplasms) :
Acute loss of
Pten leads to an increase in the abundance of p19(Arf),
p53 , and p21 proteins as part of a fail-safe senescence response
Zheng et al., J Cell Biochem 2010
(Stomach Neoplasms) :
Suppression of
PTEN expression with siRNA significantly
reduced the
p53 and p21 levels and activated Akt, resulting in decreased apoptosis and increased cell survival
Rahal et al., Carcinogenesis 2010
:
We show that increased nuclear PTEN levels initiated an autoregulatory loop involving PTEN dependent increases in p53 nuclear localization, PTEN-p53 physical association,
PTEN-p53 co-recruitment to the PTEN promoter region and
p53 transactivation of PTEN promoter activity
Pu et al., Biophys J 2010
:
Nuclear
p53 induces expression of Mdm2,
PTEN , PUMA, and Bax
He et al., Hum Mol Genet 2011
(Breast Neoplasms...) :
On the other, the mislocalized mutant
PTEN results in a significantly decreased nuclear
p53 protein level and transcriptional activity, enhanced production of reactive oxygen species, induction of Cu/Zn superoxide dismutase as well as dramatically increased DNA double-strand breaks ( DSBs )
Lehman et al., J Biol Chem 2011
:
PTEN can directly or indirectly
activate p53 to promote apoptosis
Robbins et al., FEBS Lett 2012
:
Involvement of
PTEN in TPA mediated
p53-activation in mouse skin epidermal JB6 cells ... Our findings suggest
PTEN mediates TPA induced
p53 activation
Huang et al., Neoplasia (New York, N.Y.) 2013
:
Using a wide array of molecular, genetic, and functional approaches, we demonstrate that
PTEN enhances a transcriptional complex containing gain-of-function mutant
p53 , CBP, and NFY in human glioblastoma cells and tumor tissues