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HMOX1 — IFNG
Text-mined interactions from Literome
Kitamura et al., Neurosci Lett 1999
:
However, PPARgamma activator alone induced HO-1 expression and further enhanced
LPS/IFN-gamma induced
HO-1 expression
Datta et al., Kidney Int 1999
:
HO-1 expression was also increased in
response to
LPS/IFN-gamma
Takahashi et al., J Neurochem 1999
(Glioblastoma) :
These findings raise the possibility that the expression of
heme oxygenase-1 is
down-regulated by
interferon-gamma in the nervous system
Chen et al., J Cell Biochem 2002
:
Nitric oxide and prostaglandin E2 participate in
lipopolysaccharide/interferon-gamma induced
heme oxygenase 1 and prevent RAW264.7 macrophages from UV-irradiation induced cell death
Kim et al., Exp Mol Med 2003
(Urinary Bladder Neoplasms) :
Simultaneously, TMAF induced
HO-1 and this induction was slightly
augmented by
IFN-gamma
Udono-Fujimori et al., Eur J Biochem 2004
:
Expression of
heme oxygenase-1 is
repressed by
interferon-gamma and induced by hypoxia in human retinal pigment epithelial cells
Malaguarnera et al., Int Immunopharmacol 2005
:
Moreover, co-stimulation of PRL with LPS caused activation of HMMs functions, enhancement of HO-1 expression and induction of VEGF release, whereas addition of PRL inhibited up-regulation of
HO-1 or VEGF
induced by
IFN-gamma or TNF-alpha
Wood et al., Trends Immunol 2006
:
Furthermore, it can indirectly prevent further T-cell activation by creating a microenvironment that influences the function of antigen presenting cells (APCs) as a result of
IFNgamma induced inducible nitric oxide synthase (iNOS), indoleamine-2,3-dioxygenase (IDO) and
heme oxygenase (HO)-1 expression
Lehmann et al., J Invest Dermatol 2007
:
Moreover, inhibition of
HO-1 activity
restored the diminished IL-12 and
IFNgamma production after FAE treatment
Cudmore et al., Circulation 2007
(Pre-Eclampsia) :
Adenoviral overexpression of
HO-1 in endothelial cells
inhibited VEGF mediated sFlt-1 release and
interferon-gamma- and tumor necrosis factor-alpha induced sEng release, whereas HO-1 inhibition potentiated sFlt-1 and sEng production from endothelial cells and placental villous explants