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IFNG — MMP9

Text-mined interactions from Literome

Quiding-Järbrink et al., Infect Immun 2001 (Tuberculosis) : In conclusion, we show that mycobacterial infection induces MMP-9 activity both in vitro and in vivo and that this is regulated by TNF-alpha, IL-18, and IFN-gamma
Ma et al., J Immunol 2001 : We investigated the effects of IFN-gamma and IFN-beta, cytokines used for treating some cancers and multiple sclerosis, on MMP-9 expression in human astroglioma and fibrosarcoma cell lines and primary astrocytes ... Our results demonstrate that IFN-gamma and IFN-beta significantly inhibit MMP-9 enzymatic activity and protein expression that is induced by PMA and the cytokine TNF-alpha ... The inhibitory effects of IFN-gamma and IFN-beta on MMP-9 expression correlate with decreased steady state MMP-9 mRNA levels and suppression of MMP-9 promoter activity ... IFN-gamma- and IFN-beta mediated inhibition of MMP-9 gene expression is dependent on the transcription factor STAT-1alpha, since IFN-gamma and IFN-beta fail to suppress MMP-9 expression in STAT-1alpha-deficient primary astrocytes and human fibrosarcoma cells ... Reconstitution of human STAT-1alpha successfully restores the inhibitory effects of IFN-gamma and IFN-beta on MMP-9 gene expression
Nelissen et al., J Leukoc Biol 2002 : To investigate whether a functional link exists between PECAM-1 activation and gelatinase B production, the regulatory role of PECAM-1, IFN-gamma , IFN-beta, LPS, and PMA on the production of gelatinase B ( MMP-9 ) was studied in vitro in normal human umbilical vein endothelial cells ( HUVECs ), human peripheral blood mononuclear cells ( PBMCs ), and in a human monocytic leukemia cell line
Nold et al., Naunyn Schmiedebergs Arch Pharmacol 2003 : Whereas IL-18 and TNFalpha induced the protease, MMP-9 release was not mediated by IFNgamma
Zhou et al., J Biol Chem 2003 : In contrast to its effects on MMP-1, IFNgamma inhibited TNFalpha induced MMP-9 through a caspase 8-dependent pathway as demonstrated by the restoration of MMP-9 with caspase 8 inhibitors
Nozell et al., J Biol Chem 2004 : Previous work from our laboratory has shown that interferon-gamma inhibits MMP-9 expression in a manner dependent upon STAT-1alpha
Ben-Hur et al., J Neuroimmunol 2006 : NPCs ' gelatinase activities of MMP-2 and MMP-9 , as determined by zymography, were increased by TNF-alpha, and to a lesser extent by IFN-gamma
Harris et al., FASEB J 2007 (Tuberculosis, Central Nervous System) : IFNgamma , a key cytokine in TB, usually inhibits MMP-9 secretion
Kidachi et al., Cell Biol Int 2007 (Cell Transformation, Neoplastic...) : Treatment of cells with IFN-gamma alone did not alter MMP-9 mRNA expression or pro-MMP-9 production, but LPS alone and IFN-gamma+LPS co-treatment enhanced them significantly
Wang et al., World J Gastroenterol 2008 (Liver Cirrhosis) : Both Cpd 861 and IFN-gamma reduced the mRNA levels of collagen type III, MMP-2 and TGF-beta1
Nareika et al., Atherosclerosis 2009 (Atherosclerosis...) : Results showed that high glucose and IFN gamma had a synergistic effect on the expression of MMP-1, MMP-9 and IL-1 beta
Balasubramanian et al., J Biol Chem 2011 : The interferon-gamma induced GTPase, mGBP-2, inhibits tumor necrosis factor alpha (TNF-alpha) induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-kappaB and Rac protein
Dhawan et al., J Leukoc Biol 1995 : These results indicate that the mechanism of interferon-gamma induced down-regulation of MMP-9 levels and reduced monocyte invasiveness may be mediated by a mechanism independent of antiviral activity of IFN-gamma in monocytes
Mann et al., Ann Otol Rhinol Laryngol 1995 (Carcinoma, Squamous Cell...) : Supernatants of HNSCC cell lines SCC-25 and FADU stimulated with interleukin (IL)-1 alpha and IL-1 beta demonstrated modest induction of 92 kd GL production by zymogram analysis when compared with controls ; IL-2, IL-6, and interferon-gamma had no consistent effect on MMP production
Sarén et al., J Immunol 1996 : IFN-gamma suppressed the production of the 92-kDa gelatinase induced by TNF-alpha- and IL-1beta
Varga et al., Adv Exp Med Biol 1996 : Supplementation with tryptophan completely overcame the inhibitory effects of interferon-gamma on MMP mRNA expression and metalloproteinase secretion into the media ... These results indicate that oxidative tryptophan metabolism mediates the effects of interferon-gamma on MMP gene expression in human fibroblasts
Wu et al., J Cell Physiol 1997 (Sjogren's Syndrome) : This study examined the role of IFN-gamma and ( + ) TNF-alpha in the regulation of the matrix metalloproteinases, MMP-2 ( 72 kD gelatinase A ) and MMP-9 ( 92 kD gelatinase B )