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BCR — RHOA

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of RhoA activity: BCR (BCR) → RHOA/GTP complex (RHOA) (modification, activates) Chuang et al., Proc Natl Acad Sci U S A 1995*
  Evidence: assay
• NCI Pathway Database Regulation of RhoA activity: BCR (BCR) → RHOA/GDP complex (RHOA) (modification, activates) Chuang et al., Proc Natl Acad Sci U S A 1995*
  Evidence: assay
• Reactome Reaction: BCR → RHOA (reaction) Richnau et al., J Biol Chem 2001, Krugmann et al., Mol Cell 2002, Tcherkezian et al., Biol Cell 2007, Fainstein et al., Nature 1987, Lancaster et al., J Biol Chem 1994, Yuan et al., Cancer Res 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: RHOA — BCR (direct interaction, pull down) Zhang et al., J Biol Chem 1998

Text-mined interactions from Literome

Saci et al., Mol Cell 2005 : Several lines of evidence suggest that Rho GTPases are required for B cell receptor (BCR) signaling, but whether RhoA is necessary has not been investigated ... Here, we show that RhoA is activated, downstream of PI3K, in response to BCR stimulation and is important for BCR dependent calcium flux and cell proliferation
Sahay et al., Oncogene 2008 (Cell Transformation, Neoplastic...) : p210 Bcr-Abl can stimulate RhoA activation independently of its tyrosine kinase activity, and mutations within the RhoGEF domain that are predicted to eliminate RhoGEF activity inhibit RhoA activation
Dubash et al., J Cell Biol 2013 : The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1