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NFKB1 — SGK1

Text-mined interactions from Literome

Zhang et al., Cancer Res 2005 (Breast Neoplasms) : Serum induced SGK or increased expression of SGK activated NF-kappaB transcriptional activity, whereas small interference RNA to SGK blocked NF-kappaB activity ... Coexpression of SGK and IKKbeta significantly increased the activation of NF-kappaB ( versus expression of IKKbeta alone ) ... Expression of dominant negative IKKbeta K44A, IkappaBalpha AA, and kinase-dead SGK ( 127KM ) blocked the ability of SGK to stimulate NF-kappaB activity, suggesting that IKKbeta is a target of SGK
Terada et al., J Am Soc Nephrol 2008 (Fibrosis) : In primary cultures of rat mesangial cells, aldosterone stimulated the expression, phosphorylation, and kinase activity of SGK1, as well as SGK1 dependent NF-kappaB activity
Tai et al., J Biol Chem 2009 : Furthermore, SGK1 enhanced nuclear factor kappaB (NF-kappaB) activity and up-regulated N-methyl-d-aspartate receptor NR2A and NR2B expression through activation of IKKalpha at Thr-23 and Ser-180, and these two residues play an equally important role in mediating these effects of SGK1 ... Although SGK1 does not phosphorylate IKKbeta, IKKbeta activity is still required for IKK complex activation and for SGK1 phosphorylation and activation of NF-kappaB ... In addition, SGK1 increased the acetylation of NF-kappaB through phosphorylation of p300 at Ser-1834, and this also leads to NF-kappaB activation and NR2A and NR2B expression