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GYS1 — IGF1
Text-mined interactions from Literome
Youreva et al., Can J Physiol Pharmacol 2013
:
In this study, we determined the effect of curcumin on
IGF-1 induced phosphorylation of protein kinase B (PKB),
glycogen synthase kinase-3ß ( GSK-3ß ) , and IGF-1R in VSMC
Yamamoto-Honda et al., J Biol Chem 1995
:
Upstream mechanisms of
glycogen synthase activation by insulin and
insulin-like growth factor-I ... In contrast, wortmannin and 2- ( 4-morpholinyl ) -8-phenyl-4H-1-benzopyran-4-one ( LY294002 ), inhibitors of phosphatidylinositol 3-kinase, antagonized
glycogen synthase activation in
response to insulin or
IGF-I
Cross et al., Biochem J 1994
:
The results suggest that the
stimulation of
glycogen synthase by
insulin/IGF-1 in skeletal muscle involves the MAP-KAP kinase-1 catalysed inhibition of GSK3, as well as the previously described activation of the glycogen associated form of protein phosphatase-1
Jaspers et al., J Mol Cell Cardiol 1993
(Diabetes Mellitus, Experimental...) :
The ability of insulin,
IGF-1 and IGF-2 to
stimulate the activation of
glycogen synthase in the heart was compared under completely defined conditions using primary culture cardiomyocytes ... These results suggest that ( 1 ) both insulin and
IGF-1 are potent regulators of glycogen synthesis in the heart, ( 2 ) the enzymes involved in the dephosphorylation ( activation ) of glycogen synthase are closely linked to both insulin and IGF-1, but not IGF-2 receptor signaling pathways, ( 3 ) glycogen synthase activation is adversely affected by the maintenance of cardiomyocytes in the presence of palmitate or for > or = 24 h in hormone deficient media which results in insulin and IGF-1 resistance, and ( 4 ) this resistance, like that found in cells from diabetic rats, is
due at least in part to a decrease in
glycogen synthase phosphatase activity