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GRM1 — PRKAR2B
Text-mined interactions from Literome
Miyashita et al., Receptors Channels 2000
(MAP Kinase Signaling System) :
Taken together, we concluded that the Ca2+o sensing function of
mGluR1alpha and the continuous stimulation by Ca2+o caused the increase in the basal cAMP level by direct coupling with Gs, and
triggered the subsequent activation of
PKA , MAPKK, and MAPK cascade which resulted in the morphological change of transfected CHO cells
Mundell et al., Mol Pharmacol 2004
:
In coimmunoprecipitation experiments, the ability of glutamate to increase association of GRK2 and arrestin-2 with
mGluR1a and mGluR1b was
inhibited by
PKA activation with forskolin ... Together, these results indicate that
PKA activation
inhibits the agonist induced internalization and desensitization of mGluR1a and
mGluR1b , probably by reducing their interaction with GRK2 and nonvisual arrestins